ArticleFrontiers in medicine2026
A register-based, epidemiological evaluation of disease activity and functional performance in ankylosing spondyloarthritis patients after multimodal spa therapy in Austria.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Evidence regarding the impact of multimodal treatment on disease activity and functional performance in ankylosing spondyloarthritis (AS) remains scarce. This study aims to evaluate changes in these outcomes after multimodal rehabilitation including low-dose radon, using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Functional Index (BASFI). Methods: Mixed-effects linear regression was performed on prospectively collected registry data to explore associations between timepoints and BASDAI/BASFI. Predicted linear margins from fixed effects were calculated for each timepoint. Data were derived from AS patients who underwent multimodal rehabilitation and completed questionnaires at baseline (T0), post-intervention (T1), and at 3 (T2), 6 (T3), and 9 (T4) months follow-up. Results: Two hundred fifty-seven AS patients were included (52.14 ± 10.20 years; 42.57% female, BMI: 26.64 ± 4.27 kg/m Conclusion: Significant improvements in physical functioning and disease activity among AS patients following multimodal rehabilitation including low-dose radon were found. Such interventions may serve as a valuable complement to pharmacological treatment.
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