Evidence map›Paper›PMID 41987688›Full record

ArticleChemMedChem2026

Zwitterionic Mn(III)-Tetraphenyl Porphyrins: Water-Soluble MRI Contrast Agents with High Relaxivity.

Darius Ludolfs, Lennart F V Spickschen, Stefanie Bredehöft, Verena R Schulze, Marie Oest, Samila Leon Chaviano, Neus Feliu, Markus Fischer, Marc-André Fortin, John V Frangioni and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Darius LudolfsDepartment of Chemistry, Institute of Pharmacy, Universität Hamburg, Hamburg, Germany.
Lennart F V SpickschenDepartment of Chemistry, Institute of Pharmacy, Universität Hamburg, Hamburg, Germany.
Stefanie BredehöftDepartment of Chemistry, Institute of Pharmacy, Universität Hamburg, Hamburg, Germany.
Verena R SchulzeFraunhofer Institute of Applied Polymer Research IAP, Center of Applied Nanotechnology CAN, Hamburg, Germany.
Marie OestHamburg School of Food Science, Institute of Food Chemistry, Universität Hamburg, Hamburg, Germany.
Samila Leon ChavianoAxe Oncologie, Centre de Recherche du CHU de Québec - Université Laval, Québec, Canada.
Neus FeliuFraunhofer Institute of Applied Polymer Research IAP, Center of Applied Nanotechnology CAN, Hamburg, Germany.
Markus FischerHamburg School of Food Science, Institute of Food Chemistry, Universität Hamburg, Hamburg, Germany.
Marc-André FortinAxe Oncologie, Centre de Recherche du CHU de Québec - Université Laval, Québec, Canada.
John V FrangioniCuradel Pharma, Bonita Springs, FL, USA.
Wolfgang MaisonDepartment of Chemistry, Institute of Pharmacy, Universität Hamburg, Hamburg, Germany.ORCID 0000-0003-2793-5722

Funding

Fraunhofer-Gesellschaft 178-600040
6 · The paper itself

Abstract

Manganese-based contrast agents (MBCAs) are promising alternatives to currently used gadolinium-based contrast agents (GBCAs) for magnetic resonance imaging (MRI). This study describes the synthesis and physicochemical evaluation of two new zwitterionic Mn(III) porphyrin chelates (Mn-8 and Mn-9). Both compounds were synthesized via copper-catalyzed azide-alkyne cycloaddition (CuAAC) from an azido-substituted precursor. Both zwitterionic compounds are soluble in water and are remarkably stable to acidic pH and transmetallation under challenging conditions. The complexes have a high T

Indexed as

Contrast MediaMagnetic Resonance ImagingManganeseMetalloporphyrinsAnimalsMolecular StructureSolubilityWaterContrast MediaManganesemanganese(III) porphyrinMetalloporphyrinsWatercontrast agentsmagnetic resonance imagingmanganese‐based contrast agentsporphyrinszwitterions

Identifiers

PMID41987688
PMCPMC13084297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.