Trial reportLasers in surgery and medicine2026
Pulsed 830-nm Laser Irradiation Modulates Aδ- and C-Fiber-Mediated Pain Thresholds in Healthy Adults: A Randomized, Sham-Controlled Trial.
Trial report in Lasers in surgery and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
3 authors.
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Abstract
objectivesTo determine whether pulsed near-infrared laser irradiation differentially modulates pain thresholds mediated by Aδ- and C-fibers in humans. MATERIALS AND
methodsIn this randomized, sham-controlled, single-blind, parallel-group trial, healthy adults received pulsed 830-nm laser irradiation (peak power 10 W) or sham irradiation applied to the volar forearm. Aδ- and C-fiber-mediated pain thresholds were assessed before and immediately after irradiation using intra-epidermal electrical stimulation delivered via a concentric bipolar electrode. Linear mixed-effects models were used to examine group × time interactions for each fiber types.
resultsSignificant group-by-time interactions were observed for Aδ-mediated thresholds (p = 0.034) and C-fiber-mediated thresholds (p = 0.046), indicating differential pre-post changes between the laser and sham groups. Pain thresholds increased following active irradiation in both fiber types, whereas minimal changes were observed after sham irradiation. Between-group differences in change scores were associated with moderate standardized effect sizes.
conclusionPulsed 830-nm laser irradiation induces immediate modulation of peripheral nociceptive processing in humans across Aδ- and C-fibers, supporting fiber-specific modulation of nociceptive processing under controlled experimental conditions. CLINICAL
trial registrationUniversity Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR), UMIN000056285.
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