Evidence map›Paper›PMID 41987380›Full record

ArticleThe Journal of veterinary medical science2026

Systemic apolipoprotein C-III amyloidosis in an Asian lion (Panthera leo persica).

Natsumi Kobayashi, Ayaka Shimmura, Susumu Iwaide, Kaori Ono, Yoshiyuki Itoh, Kohji Nomura, Tomoyuki Shibahara, Tomoaki Murakami

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Natsumi KobayashiTokyo University of Agriculture and Technology, Tokyo, Japan.
Ayaka ShimmuraTokyo University of Agriculture and Technology, Tokyo, Japan.
Susumu IwaideTokyo University of Agriculture and Technology, Tokyo, Japan.
Kaori OnoYokohama Greenery Foundation, Nogeyama Zoological Gardens of YOKOHAMA, Kanagawa, Japan.
Yoshiyuki ItohSmart-Core-Facility Promotion Organization, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Kohji NomuraMLT Co., Ltd., Veterinary Diagnostic Pathology Section, Osaka, Japan.
Tomoyuki ShibaharaNational Institute of Animal Health, National Agriculture and Food Research Organization (NARO), Ibaraki, Japan.
Tomoaki MurakamiTokyo University of Agriculture and Technology, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apolipoprotein C-III (ApoC-III) amyloidosis is an extremely rare systemic amyloidosis previously reported only in humans and white lions. This report describes the first case of ApoC-III amyloidosis in an Asian lion (16-year-old male) that died with clinical manifestations of renal failure. Histopathological and ultrastructural examinations identified amyloid deposits predominantly at the renal corticomedullary junction. Mass spectrometry and immunohistochemistry identified ApoC-III as an amyloid precursor protein. Sequencing of the lion's APOC3 gene found no pathogenic mutations, although lion species have a unique M30V substitution compared with other Panthera species, which may predispose them to ApoC-III amyloidosis. This first case of a non-white lion indicates that ApoC-III amyloidosis is not restricted to white lions.

Indexed as

AmyloidosisApolipoprotein C-IIILionsAnimalsAnimals, ZooFatal OutcomeMaleApolipoprotein C-IIIApolipoprotein C-IIIliquid chromatography−tandem mass spectrometrypolymerase chain reactionrenal diseasezoo animal

Identifiers

PMID41987380
PMCPMC13280096

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.