Evidence map›Paper›PMID 41987247›Full record

ArticleJournal of nanobiotechnology2026

ROS-responsive EGCG-Fe-Cur nanosystems for radioprotection through antioxidant and inhibition of ferroptosis pathways.

Xinrui Yang, Jing Liu, Ziqian Shang, Luxun Yang, Mingquan Gao, Xudong Yu, Binghui Lu, Zifei Wu, Shenglin Luo, Weidong Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xinrui Yang *State Key Laboratory of Trauma and Chemical Poisoning, Military Key Laboratory of Nanomedicine, Institute of Combined Injury, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Jing Liu *State Key Laboratory of Trauma and Chemical Poisoning, Military Key Laboratory of Nanomedicine, Institute of Combined Injury, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Ziqian Shang *State Key Laboratory of Trauma and Chemical Poisoning, Military Key Laboratory of Nanomedicine, Institute of Combined Injury, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Luxun YangState Key Laboratory of Trauma and Chemical Poisoning, Military Key Laboratory of Nanomedicine, Institute of Combined Injury, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Mingquan GaoState Key Laboratory of Trauma and Chemical Poisoning, Military Key Laboratory of Nanomedicine, Institute of Combined Injury, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Xudong YuState Key Laboratory of Trauma and Chemical Poisoning, Military Key Laboratory of Nanomedicine, Institute of Combined Injury, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Binghui LuState Key Laboratory of Trauma and Chemical Poisoning, Military Key Laboratory of Nanomedicine, Institute of Combined Injury, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Zifei WuState Key Laboratory of Trauma and Chemical Poisoning, Military Key Laboratory of Nanomedicine, Institute of Combined Injury, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Shenglin LuoState Key Laboratory of Trauma and Chemical Poisoning, Military Key Laboratory of Nanomedicine, Institute of Combined Injury, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China.
Weidong WangDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, 610041, China. wwdwyl@sina.com.
Rong LiState Key Laboratory of Trauma and Chemical Poisoning, Military Key Laboratory of Nanomedicine, Institute of Combined Injury, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China. lirongyl@tmmu.edu.cn.

Funding

Clinical Scientist Program of Sichuan Cancer Hospital YB2022003Key Projects of Sichuan Natural Science Foundation 2022NSFSC0051National Natural Science Foundation of China 82173457National Natural Science Foundation of China 82304075Postdoctoral Research Foundation of China GZC20233600
6 · The paper itself

Abstract

Acute radiation sickness (ARS) is a systemic disease caused by exposure to high doses of ionizing radiation within a short period. The development of effective high-dose radiation protectants remains a critical yet unresolved challenge in this field. The fabrication of metal-phenolic networks (MPNs) is emerging as a promising strategy for the prevention and treatment of ARS. In light of this, we have adopted a novel nano-self-assembly strategy based on metal-organic coordination synthesis to develop the EGCG-Fe-Cur nanosystem, which not only exhibits robust in vitro antioxidant activity and reactive oxygen species (ROS) responsiveness but also enhances bioavailability and water solubility, thereby minimizing adverse effects. In vitro cell studies have shown that EGCG-Fe-Cur alleviates G

Indexed as

AntioxidantsCatechinFerroptosisIronNanoparticlesRadiation-Protective AgentsReactive Oxygen SpeciesAnimalsApoptosisDNA DamageGamma RaysHumansLipid PeroxidationMiceSignal TransductionAntioxidantsCatechinepigallocatechin gallateIronRadiation-Protective AgentsReactive Oxygen SpeciesApoptosisCurcuminEpigallocatechin gallateFerroptosisRadiation protection

Identifiers

PMID41987247
PMCPMC13200374

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.