ArticleBMC ophthalmology2026
Anatomical effects of ablation of the anterior retina in small animal eyes.
Article in BMC ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo provide anatomical data after cryo and laser ablation of the anterior retina in mice, rats, and rabbits as a prerequisite to make surgical procedures in these species safer.
methods12 eyes per species of C57BL/6J wild-type (wt) mice, Brown Norway rats, and Chinchilla Bastard rabbits, respectively, were treated with laser or cryo coagulation in the anterior retina. Diode laser and cryo coagulation were applied transsclerally. The coagulation effect was evaluated histologically after three weeks and a three-dimensional (3D) reconstruction was performed from serial microscopic sections to improve visualization of the effects.
resultsLesion diameter differed significantly between cryo and laser coagulation across all species (911.61 ± 52.59 μm vs. 775.89 ± 56.11 μm, p < 0.05 for mice, 686.44 ± 42.98 μm vs. 519.19 ± 30.59 μm, p < 0.0001 for rats, 415.32 ± 28.43 μm vs. 313.65 ± 29.35 μm, p < 0.05 for rabbits). The ratio of retinal thickness before and after cryo and laser coagulation was 0.41 ± 0.01 and 0.50 ± 0.03 for mice, 0.46 ± 0.03 and 0.51 ± 0.01 for rats, and 0.45 ± 0.01 and 0.51 ± 0.01 for rabbits, respectively. No significant side effects were observed. Using segmentation and registration algorithms, the microscopic images of each stack were aligned and 3D visualized.
conclusionsCryo pretreatment of the anterior retina provided a broader-based scarring compared to laser pretreatment and can possibly help to optimize experimental vitreoretinal procedures to test the biocompatibility and function of prototype devices for retinal stimulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.