ArticleBMC psychiatry2026
Loneliness is linked to psychological pain in both euthymic patients and healthy controls: a cross-sectional study.
Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPsychological pain is a subjective distressing emotional experience associated with suicidal vulnerability independently of depressive symptom severity. Although it has been described in both clinical and non-clinical populations, little is known about psychosocial factors associated with psychological pain in euthymic patients with mood disorders and in non-clinical individuals.
objectiveTo investigate clinical and psychosocial factors associated with psychological pain in euthymic and non-clinical samples, with a particular focus on loneliness and childhood trauma.
methodsWe included 133 euthymic patients (Inventory of Depressive Symptomatology (IDS-C 30) < 11 and Young Mania Rating Scale (YMRS) < 7) and 84 non-clinical participants. Psychological pain was defined using the Physical and Psychological Pain Visual Analog Scale (PPP-VAS) and suicidal ideation with the Columbia Suicide Severity Rating Scale (C-SSRS). Loneliness and anxiety were measured respectively by the University of California Los Angeles Loneliness Scale (UCLA) and the State-Trait Anxiety Inventory (STAI-T). Childhood trauma was evaluated using the Childhood Trauma Questionnaire (CTQ). Analyses were conducted separately in each group.
resultsBoth samples were predominantly female (76% in euthymic participants and 69% in non-clinical sample) with a mean age of 40 ± 14 and 37 ± 12 years respectively. Only loneliness was associated with psychological pain in both euthymic (β = 0.058, p-value = 0.030) and non-clinical samples (β = 0.063, p-value = 0.053). Childhood trauma moderated this association in non-clinical participants (β = -0.007, p-value = 0.029, adjusted effect size R² = 0.09).
conclusionLoneliness appears to be a key psychosocial correlate of psychological pain in both euthymic and non-clinical populations. These findings support the importance of considering interpersonal factors in the assessment of psychological pain beyond acute mood episodes and to develop interventions targeting loneliness to reduce psychological pain and related negative consequences. CLINICAL TRIAL NUMBER (HEALTH DATA HUB REFERENCE): 23272722 (DATE: 26-03-2025) : This study was conducted in accordance with the French Reference Methodology MR-004 (CNIL) for research using health data that does not involve human participants. According to this framework, registration in a clinical trial registry is not required. The study was registered in the public directory of the Health Data Hub, as required for MR-004 studies, on the 26-03-2025.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.