ArticleBMC pediatrics2026
The relationship between IL-10 levels, gene polymorphisms and histiocytic necrotizing lymphadenitis in children.
Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIt has been reported that interleukin-10 (IL-10) is associated with some immune-mediated diseases; however, its relationship with histiocytic necrotizing lymphadenitis (HNL) has not been reported. This study aimed to preliminarily investigate the relationship between IL-10 and HNL.
methodsThis study included 35 children with HNL and 35 healthy controls. Plasma IL-10 levels were detected by ELISA. The gene polymorphisms at -1082A/G, -819T/C, and -592 A/C in the IL-10 promoter were analyzed by Sanger sequencing. Differences in IL-10 expression, allele and genotype frequencies between the two groups were statistically compared.
resultsIL-10 levels were significantly higher in children with HNL than in the control group (P = 0.001). However, no significant differences were observed between the two groups in allele frequencies, genotype distributions of the three IL-10 promoter polymorphisms, or the haplotypes constituted by these loci.
conclusionsThese findings suggest that IL-10 may contribute to HNL pathogenesis, while no significant association between the IL-10 promoter polymorphisms (-1082A/G, -819T/C, -592A/C) and pediatric HNL susceptibility was found in this exploratory analysis. A potential genetic association cannot be excluded and further studies with a larger sample size are warranted.
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