ArticleBMC cancer2026
Development and validation of a metabolic-inflammatory-nutritional prognostic model for esophageal squamous carcinoma.
Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe role of triglyceride-glucose (TyG) as a metabolic index in the prognosis of radical esophageal cancer remains underexplored. This study evaluated the association between TyG and postoperative prognosis in esophageal squamous cell carcinoma (ESCC) and developed a metabolic-inflammatory-nutritional (MIN) scoring model to improve prognostic assessment. MATERIALS AND
methodsThis study retrospectively analyzed 434 ESCC patients who underwent radical esophagectomy, divided into development and internal validation cohorts. A MIN score was constructed using LASSO-Cox regression, and a nomogram was developed. Performance was evaluated using C-index, ROC curves, calibration, and decision curve analysis.
resultsThe preoperative TyG index was an independent protective factor for overall survival (HR = 0.44, 95% CI: 0.30–0.64, P < 0.001). The MIN score showed good discriminative ability in the derivation cohort, with 1-, 3-, and 5-year AUC values of 0.749, 0.752, and 0.760, respectively, and maintained robust performance in the validation cohort (AUC: 0.747, 0.724, and 0.728). The nomogram incorporating the MIN score, age, sex, and TNM stage achieved excellent discrimination, with C-indices of 0.832 in the derivation cohort and 0.799 in the validation cohort.
conclusionThe preoperative TyG index is a protective prognostic factor in ESCC. The MIN score and nomogram provide a robust tool for individualized prognosis prediction, complementing TNM staging.
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