ReviewMethods in molecular biology (Clifton, N.J.)2026
Perspectives of Gene Editing for the Conservation of Plant Genetic Resources.
Review in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
5 authors.
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Abstract
The rapid development of genome editing tools, particularly CRISPR-Cas9 and virus-induced genome editing (VIGE), offers transformative opportunities for the conservation of plant genetic resources. These technologies enable precise modifications that can enhance genetic variation, restore endangered populations, and strengthen resilience against climate change and invasive species. This chapter reviews methodological frameworks, including guide design, delivery systems, regeneration protocols, and verification of off-target effects, as well as ecological and ethical considerations. Case studies are highlighted in both wild and cultivated species: American chestnut, ash, elm, Pacific yew, hemlock, and whitebark pine, alongside crops of global significance such as coffee, cacao, wild apple, and banana. Applications include resistance to blight, borers, Dutch elm disease, woolly adelgid, rust, rots, and endogenous viral elements. Finally, the chapter outlines future directions emphasizing biosafety, ecological validation, and equitable governance, underscoring the potential of CRISPR-based strategies to integrate conservation science with sustainable agricultural practices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.