Evidence map›Paper›PMID 41986789›Full record

ArticleOphthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)2026

Nasotemporal Asymmetry in Ocular Biometry as a Biomarker for Myopia Progression in Chinese Children.

Tianli Peng, Li Zhang, Wenjun Xu, Meijun Wang, Ningli Wang, David A Atchison, Shi-Ming Li

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Tianli PengBeijing Tongren Eye Centre, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, National Engineering Research Centre for Ophthalmology, Capital Medical University, Beijing, China.
Li ZhangBeijing Tongren Eye Centre, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, National Engineering Research Centre for Ophthalmology, Capital Medical University, Beijing, China.
Wenjun XuBeijing Tongren Eye Centre, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, National Engineering Research Centre for Ophthalmology, Capital Medical University, Beijing, China.
Meijun WangBeijing Tongren Eye Centre, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, National Engineering Research Centre for Ophthalmology, Capital Medical University, Beijing, China.
Ningli WangBeijing Tongren Eye Centre, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, National Engineering Research Centre for Ophthalmology, Capital Medical University, Beijing, China.
David A AtchisonCentre for Vision and Eye Research, Queensland University of Technology, Brisbane, Australia.
Shi-Ming LiBeijing Tongren Eye Centre, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, National Engineering Research Centre for Ophthalmology, Capital Medical University, Beijing, China. lishiming81@163.com.

Funding

Beijing Natural Science Foundation L248023, JQ20029Capital health research and development of special grant 2024-2G-1081the Beijing New-star Plan of Science and Technology Cross-cooperation Project 20250484983the Excellent Youth Talents Program of Capital Medical University A2307the National Key R&D Program of China 2022YFC3502502the National Natural Science Foundation of China 82071000, 82471113the National Outstanding Young Physician Project; the Beijing High-Level Innovation and Entrepreneurship Talent Support Program Leading Talent Projects G202512030
6 · The paper itself

Abstract

purposeThis multicentre longitudinal study investigated nasotemporal retinal asymmetry as a geometric biomarker for monitoring myopia risk in children.

methodA total of 2520 Chinese children (Beijing cohort: N = 49, 5-14 years old; Anyang cohort: N = 2471, 6-9 years old) underwent annual measurements over 2 years, including axial length (AL), central spherical equivalent (CSE) and peripheral AL (30° nasal, temporal, superior, inferior) in the Beijing cohort and horizontal meridian peripheral refractions (±15°, ±30°) in the Anyang cohort. Retinal morphology was quantified through the vertex radius of curvature, asphericity and areas under the horizontal nasal and temporal retinal curve (AUHRCn and AUHRCt, respectively). Nasotemporal retinal asymmetry was defined as AUHRCt/n. Vertical asymmetry was defined as superior peripheral AL/inferior peripheral AL. Participants from the Anyang cohort were stratified into persistent myopia (myopic at baseline), newly developed myopia (myopia onset during follow-up) and persistent non-myopia (remained non-myopic over 2 years).

resultIn the Beijing cohort, the temporal-to-nasal AL ratio was the only factor significantly associated with myopic progression (ΔAL: r = -0.36, p = 0.01; ΔCSE: r = 0.37, p = 0.01). Validating this, in the Anyang cohort, decreasing AUHRCn preceded myopia onset, followed by progressive temporal steepening. Linear regression identified baseline AUHRCt/n as an independent negative predictor of myopic progression (β = 2.90, p = 0.03). A model incorporating baseline AUHRCt/n improved the prediction of progression risk (integrated discrimination improvement (IDI) = 3.74%, p = 0.03).

conclusionProgressive nasotemporal retinal asymmetry, particularly temporal steepening, precedes clinical myopia onset and was correlated with future refractive progression. This geometric biomarker shows potential for identifying myopic risk up to 2 years before manifest refraction changes, enabling earlier preventive interventions.

Indexed as

Axial Length, EyeBiometryMyopiaRefraction, OcularRetinaAdolescentBiomarkersChildChild, PreschoolChinaDisease ProgressionEast Asian PeopleFemaleFollow-Up StudiesHumansLongitudinal StudiesBiomarkersAnyang Childhood Eye StudyGeometric biomarkerMyopia progressionPaediatric myopiaRetinal asymmetry

Identifiers

PMID41986789

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.