Trial reportLasers in medical science2026
Efficacy and safety of micro-focused ultrasound for middle and lower face rejuvenation: A prospective study.
Trial report in Lasers in medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate the efficacy and safety of micro-focused ultrasound (MFUS) for rejuvenation of the middle and lower face in Chinese patients. This prospective, single-arm, interventional study enrolled 20 Chinese patients with facial laxity. All received a single session of treatment with the Peninsula MFUS device. Efficacy was assessed by two independent, blinded dermatologists using paired, standardized pre- and post-treatment photographs and the validated 5-point Investigator Global Aesthetic Improvement Scale (IGAIS). A novel quantitative metric - the reduction in a defined mandibular area (Area x) calculated from standardized lateral photographs - was employed to objectively measure tissue lift. Patient satisfaction and treatment-related adverse events were recorded. All participants completed the 6-month follow-up. Based on pooled IGAIS scores from both assessors, 100% of patients showed improvement at 3 and 6 months. The peak response was observed at 3 months, with 32.5% rated as “very much improved” and 57.5% as “much improved”. The quantitative mandibular area (Area x) showed a statistically significant reduction from baseline at 1 month (P < 0.0001) and 3 months (P = 0.0116), indicating objective tissue lift. Overall patient satisfaction was high (100% satisfied at 3 months). No major complications occurred. The most common side effect was transient, mild-to-moderate muscle pain (reported by 90% of participants, median duration 6 days). In this prospective pilot study, MFUS treatment was effective and well-tolerated for tightening the middle and lower face in Chinese patients, providing both subjective improvement and objective evidence of mandibular lift. The treatment demonstrated a favorable safety profile.
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