Evidence map›Paper›PMID 41986756›Full record

ReviewAdvanced biotechnology2026

The potential of metabolic engineering for sustainable phytosterol production.

Runmeng Hu, Xueni Di, Guangli Li, Hubert Schaller, Andréa Hemmerlin, Pan Liao

Abstract readReview
In one paragraph

Review in Advanced biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Runmeng HuDepartment of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China.
Xueni DiDepartment of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China.
Guangli LiDepartment of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China.
Hubert SchallerInstitut de Biologie Moléculaire Des Plantes (IBMP), Centre National de La Recherche Scientifique, Université de Strasbourg, 12 Rue du Général Zimmer, 67084, Strasbourg, France.
Andréa HemmerlinInstitut de Biologie Moléculaire Des Plantes (IBMP), Centre National de La Recherche Scientifique, Université de Strasbourg, 12 Rue du Général Zimmer, 67084, Strasbourg, France.
Pan LiaoDepartment of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. panliao@hkbu.edu.hk.ORCID http://orcid.org/0000-0002-1156-8916

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phytosterols, essential components pivotal to plant membrane stability and celebrated for their extensive pharmacological benefits, have garnered considerable attention across industries, including food fortification, nutraceuticals, and pharmaceuticals. The escalating demand for phytosterols, fueled by their myriad health advantages, underscores the urgent need for more efficient synthesis methodologies. Among these, metabolic engineering stands out as a promising approach due to its biologically driven process, which operates under stable conditions, thereby enhancing reaction specificity and drastically reducing the production of undesirable by-products. This review consolidates the latest research endeavors focused on enhancing phytosterol accumulation, providing a comprehensive analysis of strategies including gene manipulation, enzyme engineering, metabolic engineering, and the utilization of diverse host organisms such as bacteria, algae, and yeast. We explore recent advancements in phytosterol biosynthesis and engineering, providing a comprehensive overview of the field's current state and examining promising methodologies for future research and applications.

Indexed as

BiosynthesisHeterologous ProductionMetabolic EngineeringPhytosterol

Identifiers

PMID41986756
PMCPMC13083469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.