ArticlePediatric research2026
Cross-sectional associations of clinical predictors and physical activity in pediatric inflammatory bowel disease.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundReduced physical activity (PA) is common in pediatric inflammatory bowel disease (IBD) and may compromise health. This study aimed to examine cross-sectional associations between PA and biomedical, treatment-related, and clinical-psychosocial factors.
methodsSingle-center cross-sectional study of 45 patients (9-18 years) with Crohn's disease or ulcerative colitis. PA was assessed using Assessment of Physical Activity Levels Questionnaire (APALQ), and health-related quality of life (HRQoL) using IMPACT-III questionnaire. Inflammatory biomarkers, treatment exposure, joint involvement, and disease characteristics were obtained from medical records. Separate multiple linear regression models were constructed for biomarker, treatment, and clinical-demographic domains and adjusted for age and sex.
resultsLower PA levels were observed in patients with poorer HRQoL, joint involvement, and higher inflammation. In the clinical-demographic model (R² = 0.39, p = 0.009, n = 38), PA was positively associated with HRQoL (β = 0.46, p = 0.004) and negatively associated with joint involvement (β = -0.28, p = 0.041). In the biomarker model (R² = 0.23, p = 0.042, n = 37), higher fecal calprotectin was associated with lower PA (β = -0.41, p = 0.018). Treatment-related variables were not significantly associated with PA (R² = 0.18, p = 0.281, n = 29).
conclusionsIn pediatric IBD, PA is primarily influenced by quality of life, joint involvement, and inflammatory activity rather than treatment exposure, supporting multidisciplinary strategies addressing psychosocial well-being, joint involvement and disease control. IMPACT: Provides novel evidence to guide multidisciplinary management strategies in pediatric IBD. Highlights the key role of psychosocial and musculoskeletal factors in shaping activity participation in pediatric IBD. Suggests that interventions to promote physical activity should target quality of life and joint involvement rather than solely biomedical parameters.
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