Evidence map›Paper›PMID 41986745›Full record

ArticleMolecular psychiatry2026

Loss of schizophrenia risk gene XPO7 disrupts neuronal excitability and network regularity via altered Na

Lei Cui, Erkin Kurganov, Derek Hawes, Philipp Hornauer, Raozhou Lin, Yining Wang, Andreas Hierlemann, Morgan Sheng, Ralda Nehme, Jen Q Pan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lei CuiStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, MA 02115, USA.ORCID http://orcid.org/0009-0007-3679-4569
Erkin KurganovStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, MA 02115, USA.
Derek HawesStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, MA 02115, USA.
Philipp HornauerDepartment of Biosystems Science and Engineering, ETH Zürich, 4056, Basel, Switzerland.ORCID http://orcid.org/0000-0003-2265-6679
Raozhou LinStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, MA 02115, USA.ORCID http://orcid.org/0000-0002-1066-8464
Yining WangStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, MA 02115, USA.
Andreas HierlemannDepartment of Biosystems Science and Engineering, ETH Zürich, 4056, Basel, Switzerland.
Morgan ShengStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, MA 02115, USA.ORCID http://orcid.org/0000-0002-8703-5366
Ralda NehmeStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, MA 02115, USA.ORCID http://orcid.org/0000-0001-7215-3311
Jen Q PanStanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, 75 Ames Street, Cambridge, MA 02115, USA. jpan@broadinstitute.org.ORCID http://orcid.org/0000-0003-0767-086X

Funding

Potentiate Cav3.3 To Treat Cognitive Deficits Associated with Impaired Sleep SpindleRF1MH131719 · NIMH · BROAD INSTITUTE, INC. · PI PAN, JEN QIAN, WEÏWER, MICHEL · 2025 to 2025
$2.1M
Potentiate Cav3.3 To Treat Cognitive Deficits Associated with Impaired Sleep SpindleR01MH131719 · NIMH · BROAD INSTITUTE, INC. · PI PAN, JEN QIAN, WEÏWER, MICHEL · 2022 to 2023
$1.8M
SyncroPatch 384 Automated Patch Clamp InstrumentS10MH133644 · NIMH · BROAD INSTITUTE, INC. · PI PAN, JEN QIAN · 2023 to 2023
$600k
Broad Institute | Stanley Center for Psychiatric Research, Broad Institute (Stanley Center) RNNIMH NIH HHS R01 MH131719NIMH NIH HHS RF1 MH131719NIMH NIH HHS S10 MH133644U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH131719U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) S10MH133644
6 · The paper itself

Abstract

Schizophrenia is a highly heritable psychiatric disorder, yet the molecular mechanisms by which genetic risk contributes to disease pathophysiology remain largely unknown. In this study, we investigate the functional consequences of XPO7 loss of function (LoF) in human induced pluripotent stem cell (iPSC)-derived neurons, focusing on its role as a schizophrenia risk gene identified through recent large-scale exome sequencing analyses. By integrating high-precision electrophysiological measurements with transcriptomic, proteomic, and imaging approaches, we demonstrate that XPO7 LoF alters Na

Indexed as

KaryopherinsReceptors, Cytoplasmic and NuclearSchizophreniaGenetic Predisposition to DiseaseHumansInduced Pluripotent Stem CellsLoss of Function MutationNAV1.2 Voltage-Gated Sodium ChannelNeuronsSodium ChannelsKaryopherinsNAV1.2 Voltage-Gated Sodium ChannelReceptors, Cytoplasmic and NuclearSCN2A protein, humanSodium Channels

Identifiers

PMID41986745
PMCPMC13441981

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.