Evidence map›Paper›PMID 41986721›Full record

ArticleNature2026

Ancient DNA reveals pervasive directional selection across West Eurasia.

Ali Akbari, Annabel Perry, Alison R Barton, Mohammadreza Kariminejad, Steven Gazal, Zheng Li, Yating Zeng, Alissa Mittnik, Nick Patterson, Matthew Mah and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ali AkbariDepartment of Genetics, Harvard Medical School, Boston, MA, USA. Ali_Akbari@fas.harvard.edu.ORCID http://orcid.org/0000-0002-5000-5876
Annabel PerryDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Alison R BartonDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Mohammadreza KariminejadShamsipour Technical and Vocational College, Tehran, Iran.
Steven GazalDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Zheng LiDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-5826-1316
Yating ZengDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0009-0006-8968-5932
Alissa MittnikDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6963-4824
Nick PattersonDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-0302-684X
Matthew MahDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8987-6436
Xiang ZhouDepartment of Statistics and Data Science, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-4331-7599
Alkes L PriceBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Eric S LanderBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Ron PinhasiDepartment of Evolutionary Anthropology, University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0003-1629-8131
Nadin RohlandDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Swapan MallickDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4531-4439
David ReichDepartment of Genetics, Harvard Medical School, Boston, MA, USA. reich@genetics.med.harvard.edu.ORCID http://orcid.org/0000-0002-7037-5292

Funding

Solving ascertainment bias in ancient DNA using Ultima Genomics sequencingR01HG012287 · NHGRI · HARVARD MEDICAL SCHOOL · PI REICH, DAVID E · 2021 to 2025
$2.7M
Howard Hughes Medical InstituteNHGRI NIH HHS R01 HG012287
6 · The paper itself

Abstract

Ancient DNA has transformed our understanding of population history

Indexed as

DNA, AncientSelection, GeneticAllelesAsiaEuropeEvolution, MolecularGene FrequencyHistory, AncientHumansPhenotypeDNA, Ancient

Identifiers

PMID41986721
PMCPMC13189228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.