Evidence map›Paper›PMID 41986711›Full record

ArticleNature2026

Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers.

Julian R Buissant des Amorie, Joris H Hageman, Sascha R Brunner, Suzanne E M van der Horst, Maria C Puschhof, Arne van Hoeck, Inge van Lierop, Sjors Middelkamp, Lisa van der Schee, Sven van Kempen and 12 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Niches in cancer: from primary tumors to metastatic disease.Journal of hematology & oncology · 2026
    Review
  2. Single-cell epigenomics of colorectal cancer.Experimental & molecular medicine · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Julian R Buissant des Amorie *Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0009-0000-0257-9181
Joris H Hageman *Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0002-1386-054X
Sascha R Brunner *Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0009-0003-6579-1587
Suzanne E M van der Horst *Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Maria C PuschhofCenter for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0003-2866-9155
Arne van HoeckCenter for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Inge van LieropCenter for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Sjors MiddelkampCenter for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Lisa van der ScheeDepartment of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands.
Sven van KempenDepartment of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0009-0006-5079-0639
Folkert MorsinkDepartment of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands.
Robin GeeneCenter for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Sander MertensCenter for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
David S CavigelliCenter for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Ingrid Verlaan-KlinkCenter for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
Lianne J KraaierIndependent Researcher, Utrecht, the Netherlands.
Jorieke SalijUtrecht Platform for Organoid Technology, Utrecht, the Netherlands.
Renate BezemerUtrecht Platform for Organoid Technology, Utrecht, the Netherlands.
Onno KranenburgUtrecht Platform for Organoid Technology, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0002-2112-4390
Miangela M LacléDepartment of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands.
Leon M G MoonsDepartment of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, the Netherlands.
Hugo J G SnippertCenter for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands. h.j.g.snippert-2@prinsesmaximacentrum.nl.ORCID http://orcid.org/0000-0002-4189-5213

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastasis formation is classically considered a late-stage event in colorectal cancer evolution. Yet the time and spatial patterning by which metastatic competence is acquired remain poorly understood

Indexed as

Cell PlasticityColorectal NeoplasmsAnimalsCell Transformation, NeoplasticCoculture TechniquesDisease ProgressionFemaleFibroblastsHumansMaleMiceNeoplasm InvasivenessNeoplasm MetastasisOrganoidsTumor Microenvironment

Identifiers

PMID41986711
PMCPMC13233332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.