Evidence map›Paper›PMID 41986709›Full record

ArticleNature2026

Template-driven scaffolding of SCF

Sebastien Coassolo, Nairie Michaelian, Timurs Maculins, Caleigh M Azumaya, Tommy K Cheung, Jianping Yin, Inna Zilberleyb, Kanika Bajaj Pahuja, Thomas Garner, Ted Lau and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sebastien Coassolo *Department of Discovery Oncology, Genentech, South San Francisco, CA, USA.
Nairie Michaelian *Department of Structural Biology, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1605-1788
Timurs Maculins *Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-9333-301X
Caleigh M AzumayaDepartment of Structural Biology, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3484-9921
Tommy K CheungDepartment of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA.
Jianping YinDepartment of Structural Biology, Genentech, South San Francisco, CA, USA.
Inna ZilberleybDepartment of BioMolecular Research, Genentech, South San Francisco, CA, USA.
Kanika Bajaj PahujaDepartment of BioMolecular Research, Genentech, South San Francisco, CA, USA.
Thomas GarnerDepartment of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, CA, USA.
Ted LauDepartment of Discovery Oncology, Genentech, South San Francisco, CA, USA.
Davis MauDepartment of Dermatology, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0009-0002-3441-1249
Matthew GrimmerDepartment of Discovery Oncology, Genentech, South San Francisco, CA, USA.
Jean-Philippe FortinDepartment of Bioinformatics, Genentech, South San Francisco, CA, USA.
Mike CostaDepartment of Discovery Oncology, Genentech, South San Francisco, CA, USA.
Yoana N DimitrovaDepartment of Structural Biology, Genentech, South San Francisco, CA, USA.
Christopher M RoseDepartment of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA.
Peter L HsuDepartment of Structural Biology, Genentech, South San Francisco, CA, USA. hsup2@gene.com.ORCID http://orcid.org/0000-0002-9381-6564
Robert L YauchDepartment of Discovery Oncology, Genentech, South San Francisco, CA, USA. bobyauch@gene.com.ORCID http://orcid.org/0000-0001-9478-6283

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein phosphatase 2A (PP2A) is a Ser/Thr phosphatase that regulates the phosphorylation of almost all cellular processes, including cell division and proliferation

Indexed as

F-Box ProteinsProtein Phosphatase 2ProteolysisAnimalsCatalytic DomainCell Line, TumorCryoelectron MicroscopyHoloenzymesHumansModels, MolecularProtein MultimerizationProtein Structure, QuaternarySKP Cullin F-Box Protein LigasesSubstrate SpecificityUbiquitinationF-Box ProteinsFBXO42 protein, humanHoloenzymesProtein Phosphatase 2SKP Cullin F-Box Protein Ligases

Identifiers

PMID41986709
PMCPMC13233325

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.