Evidence map›Paper›PMID 41986707›Full record

ArticleNature2026

Linear RAG scanning mediates editing of Igκ variable region repertoires.

Xiang Li, Hongli Hu, Yiwen Zhang, Tammie Zhu, Ying Guan, Kai Xu, Xin Lin, Camille Hebert, Himanshu Batra, Jenny Zhou and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiang Li *Program in Cellular and Molecular Medicine, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.
Hongli Hu *Program in Cellular and Molecular Medicine, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1932-5027
Yiwen Zhang *Program in Cellular and Molecular Medicine, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.
Tammie ZhuProgram in Cellular and Molecular Medicine, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.
Ying GuanProgram in Cellular and Molecular Medicine, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.
Kai XuProgram in Cellular and Molecular Medicine, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.
Xin LinProgram in Cellular and Molecular Medicine, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.
Camille HebertProgram in Cellular and Molecular Medicine, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0009-0003-3260-5725
Himanshu BatraProgram in Cellular and Molecular Medicine, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.
Jenny ZhouProgram in Cellular and Molecular Medicine, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.
Zhaoqing BaProgram in Cellular and Molecular Medicine, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8431-5469
Duane R WesemannDivision of Allergy and Clinical Immunology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Adam Yongxin YeProgram in Cellular and Molecular Medicine, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA. yongxin.ye@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-1542-0740
Frederick W AltProgram in Cellular and Molecular Medicine, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA. alt@enders.tch.harvard.edu.

Funding

Mechanisms that Control IgH Variable Region Exon AssemblyR01AI020047 · NIAID · IMMUNE DISEASE INSTITUTE, INC. · PI ALT, FREDERICK W. · 1985 to 2025
$14.1M
NIAID NIH HHS R01 AI020047
6 · The paper itself

Abstract

V(D)J recombination-mediated Igκ light chain variable region exon assembly in precursor (pre)-B cells involves recombination activating gene (RAG) endonuclease-orchestrated cleavage between and joining of paired Vκ and Jκ gene segments and flanking RAG-targeting recombination signal sequences (RSSs)

Indexed as

DNA-Binding ProteinsHomeodomain ProteinsImmunoglobulin kappa-ChainsImmunoglobulin Variable RegionV(D)J RecombinationAnimalsCCCTC-Binding FactorGene EditingHumansImmunoglobulinsInduced Pluripotent Stem CellsMicePrecursor Cells, B-LymphoidCCCTC-Binding FactorDNA-Binding ProteinsHomeodomain ProteinsIgKImmunoglobulin kappa-ChainsImmunoglobulinsImmunoglobulin Variable RegionRAG-1 protein

Identifiers

PMID41986707
PMCPMC13190342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.