Evidence map›Paper›PMID 41986697›Full record

ArticleNature biotechnology2026

Structure-centric searching enables global mapping of the public metabolome.

Yasin El Abiead, Jeong In Seo, Vincent Charron-Lamoureux, Michael Strobel, Wilhan Donizete Gonçalves Nunes, Haoqi Nina Zhao, Kine Eide Kvitne, Simone Zuffa, Helena Mannochio-Russo, Harsha Gouda and 21 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Alkamines reveal a hidden layer of steroid and drug metabolism.bioRxiv : the preprint server for biology · 2026
    Article
  4. Pan-Metabolomics Repository Mapping of the Carnitine Landscape.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Yasin El AbieadSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA. elabiead@gmail.com.ORCID http://orcid.org/0000-0003-4392-7706
Jeong In SeoSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0003-0365-925X
Vincent Charron-LamoureuxSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0001-9440-7036
Michael StrobelDepartment of Computer Science and Engineering, University of California Riverside, Riverside, CA, USA.
Wilhan Donizete Gonçalves NunesSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-0609-6678
Haoqi Nina ZhaoSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0003-3908-630X
Kine Eide KvitneSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Simone ZuffaSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0001-7237-3402
Helena Mannochio-RussoSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-4961-2353
Harsha GoudaSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Cristina BezInternational Center for Genetic Engineering and Biotechnology, Trieste, Italy.
Abubaker PatanSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Shipei XingSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Jasmine ZemlinSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Ipsita MohanyDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA.
Julius AgongoSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Andres Mauricio Caraballo RodriguezSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Lindsey A BurnettDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-6430-4498
Victoria DeleraySkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Abzer K Pakkir ShahInterfaculty Institute of Microbiology and Infection Medicine, University of Tuebingen, Tuebingen, Germany.
Jarmo-Charles KalinskiBiotechnology Innovation Centre, Rhodes University, Makhanda, South Africa.
Daniel PetrasDepartment of Biochemistry, University of California Riverside, Riverside, CA, USA.ORCID http://orcid.org/0000-0002-6561-3022
Nikiforos AlygizakisEnvironmental Institute, Koš, Slovak Republic.ORCID http://orcid.org/0000-0002-5727-4999
Jeremy CarverSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Ozgur YurektenEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK.
Thomas PayneEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK.
Eoin FahyDepartment of Bioengineering, San Diego Supercomputer Center, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-3196-522X
Shankar SubramaniamDepartment of Bioengineering, San Diego Supercomputer Center, University of California San Diego, La Jolla, CA, USA.
Juan Antonio VizcaínoEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK.ORCID http://orcid.org/0000-0002-3905-4335
Mingxun WangDepartment of Computer Science and Engineering, University of California Riverside, Riverside, CA, USA. mingxun.wang@cs.ucr.edu.ORCID http://orcid.org/0000-0001-7647-6097
Pieter C DorresteinSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA. pdorrestein@health.ucsd.edu.ORCID http://orcid.org/0000-0002-3003-1030

Funding

REPRODUCTIVE SCIENTIST TRAINING PROGRAMK12HD000849 · NICHD · WASHINGTON UNIVERSITY · PI Danny J Schust · 1988 to 2026
$33.2M
Metabolomics Workbench - National Metabolomics Data RepositoryU24DK141185 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Shankar Subramaniam · 2024 to 2026
$4.2M
Collaborative Microbial Metabolite CenterU24DK133658 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIETER C DORRESTEIN · 2022 to 2026
$2.9M
NICHD NIH HHS K12 HD000849NIDDK NIH HHS U24 DK133658NIDDK NIH HHS U24 DK141185Österreichischen Akademie der Wissenschaften (Austrian Academy of Sciences) APART-USAU.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) U24DK133658
6 · The paper itself

Abstract

Searching and learning from aggregated public metabolomics data spanning thousands of studies remained largely inaccessible. Here we present StructureMASST, a web-based application enabling scalable, structure-centric searches across public metabolomics repositories using molecule names or chemical representations. It queries a precomputed knowledgebase of 2.19 billion spectral matches and 420 million metadata links, supports modification-tolerant and mass-shift searches, and maps chemical structures across taxonomy, biological context and environmental conditions to accelerate discovery.

Identifiers

PMID41986697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.