Evidence map›Paper›PMID 41986689›Full record

ArticleNature chemistry2026

KDM3A catalyses the oxidation of acetyl-lysine to hydroxyacetyl-lysine on histone H3K9.

Roman Belle, John-Paul Bukowski, Rachel Schiller, Ronald Cutler, Eidarus Salah, Robert S Dawber, Anthony Tumber, Joanna Bonnici, Jessica D Kindrick, Loane Serrano and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Roman Belle *Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
John-Paul Bukowski *Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.ORCID 0009-0000-2287-4006
Rachel Schiller *Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Ronald CutlerAlbert Einstein College of Medicine, Bronx, NY, USA.
Eidarus SalahChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Robert S DawberChemistry - School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-9802-2691
Anthony TumberChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Joanna BonniciChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.ORCID 0000-0002-2723-6895
Jessica D KindrickNuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0003-1519-9721
Loane SerranoChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Patrick RabeChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.ORCID 0000-0002-3448-9559
Catrine JohanssonChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Marie-Hélène RuchaudChemistry - School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, UK.
Richard J HopkinsonChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.ORCID 0000-0001-7610-8163
William D FiggCenter for Cancer Research and National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-2428-5613
Paul E BrennanNuffield Department of Medicine, University of Oxford, Oxford, UK.
David R MoleNuffield Department of Medicine, University of Oxford, Oxford, UK.
Simone SidoliAlbert Einstein College of Medicine, Bronx, NY, USA.
Akane KawamuraChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK. akane.kawamura@newcastle.ac.uk.ORCID 0000-0003-1169-5082
Christopher J SchofieldChemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK. christopher.schofield@chem.ox.ac.uk.ORCID 0000-0002-0290-6565

Funding

Drug Development for Prostate Cancer and other Metastatic ProcessesZIABC010547 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI FIGG, WILLIAM DOUGLAS · 2009 to 2025
$10.2M
Orbitrap Exploris 480 Basic SystemS10OD030286 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SIDOLI, SIMONE · 2021 to 2021
$600k
Cancer Research UK (CRUK) C8717/A18245Cancer Research UK (CRUK) C8717/A28285EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 101003111EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 679479NIH HHS S10 OD030286RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/G037280/1RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/L015838/1RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/N509711/1U.S. Department of Health & Human Services | National Institutes of Health (NIH) ZIA BC 010547Wellcome Trust (Wellcome) 106244/Z/14/ZWellcome Trust (Wellcome) 227298/Z/23/Z
6 · The paper itself

Abstract

Histone modifications, including N

Indexed as

HistonesJumonji Domain-Containing Histone DemethylasesLysineAcetylationBiocatalysisHumansOxidation-ReductionHistonesJumonji Domain-Containing Histone DemethylasesKDM3A protein, humanLysine

Identifiers

PMID41986689
PMCPMC13149330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.