Evidence map›Paper›PMID 41986652›Full record

ArticleOncogene2026

Role of SCAP in regulation of pancreatic homeostasis, pancreatitis, and tumorigenesis.

Anna C Lilly, Valerii A Pavlov, Shabnam Pirestani, Adam Chatoff, Kathy Q Cai, Edna Cukierman, Nathaniel W Snyder, Igor Astsaturov, Erica A Golemis

Abstract read
In one paragraph

Article in Oncogene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anna C LillyProgram in Cancer Signaling and Microenvironment, Fox Chase Cancer Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-0385-6088
Valerii A PavlovProgram in Cancer Signaling and Microenvironment, Fox Chase Cancer Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-8139-9978
Shabnam PirestaniProgram in Cancer Signaling and Microenvironment, Fox Chase Cancer Center, Philadelphia, PA, USA.
Adam ChatoffAging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Kathy Q CaiProgram in Cancer Signaling and Microenvironment, Fox Chase Cancer Center, Philadelphia, PA, USA.
Edna CukiermanProgram in Cancer Signaling and Microenvironment, Fox Chase Cancer Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1452-9576
Nathaniel W SnyderAging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-5643-8747
Igor AstsaturovProgram in Cancer Signaling and Microenvironment, Fox Chase Cancer Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-8613-1890
Erica A GolemisProgram in Cancer Signaling and Microenvironment, Fox Chase Cancer Center, Philadelphia, PA, USA. Erica.Golemis@fccc.edu.ORCID http://orcid.org/0000-0003-3618-3673

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI DAVID L. WIEST · 1985 to 2026
$138.8M
Refolding Mutant p53: A Strategy for Cancer Prevention in Li-Fraumeni SyndromeU54CA272686 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Edna Cukierman · 2022 to 2026
$8.3M
Pancreatic Cancer-Associated Fibroblasts: Function, Detection, and RegulationR01CA269660 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Edna Cukierman · 2022 to 2026
$3.1M
Multiphoton microscopy systemS10OD023666 · OD · RESEARCH INST OF FOX CHASE CAN CTR · PI YEN, TIMOTHY · 2018 to 2018
$600k
NCI NIH HHS P30 CA006927NCI NIH HHS R01 CA269660NCI NIH HHS U54 CA272686NIH HHS S10 OD023666U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA06927U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA269660U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA298386
6 · The paper itself

Abstract

Levels of pancreatic ductal adenocarcinoma (PDAC) are increasing, with epidemiological studies nominating obesity, altered cholesterol metabolism, and elevated lipids as risk factors. In prior studies, we determined that elevated expression of sterol regulatory element binding protein 2 (SREBP2), a transcription factor directing lipid biosynthesis, promoted epithelial-mesenchymal transition and aggressive tumorigenesis in the KPC (LSL-Kras

Indexed as

CarcinogenesisCarcinoma, Pancreatic DuctalIntracellular Signaling Peptides and ProteinsMembrane ProteinsPancreasPancreatic NeoplasmsPancreatitisAnimalsHomeostasisHumansMiceSterol Regulatory Element Binding Protein 2Intracellular Signaling Peptides and ProteinsMembrane ProteinsSREBP cleavage-activating proteinSterol Regulatory Element Binding Protein 2

Identifiers

PMID41986652
PMCPMC13190320

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.