Evidence map›Paper›PMID 41986618›Full record

ArticleNature plants2026

Genome-host association mapping reveals wheat pathogen genes involved in host specialization.

Cécile Lorrain, Alice Feurtey, Julien Alassimone, Bruce A McDonald

Abstract read
In one paragraph

Article in Nature plants, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cécile LorrainPlant Pathology Group, Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland. cecile.lorrain@usys.ethz.ch.ORCID http://orcid.org/0000-0001-9727-2616
Alice FeurteyPlant Pathology Group, Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland.
Julien AlassimonePlant Pathology Group, Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-8118-2605
Bruce A McDonaldPlant Pathology Group, Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-5332-2172

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant-pathogenic microorganisms, including the wheat fungal pathogen Zymoseptoria tritici, adapt to their host environment. In plants, genome-wide association studies (GWAS) have been extensively used to uncover the complexity of local adaptation and disease resistance. However, the application of GWAS to decipher the mechanisms underlying fungal pathogenicity and host adaptation trails far behind. Here we established a genome-host association approach to infer statistical associations between pathogen allele frequencies and host of origin for 832 fungal strains isolated from 12 different host cultivars during a natural field epidemic. We identified 2 to 20 genes associated with specialization to the different wheat cultivars, including one known effector gene, Avr3D1, as well as ten pathogenicity-related genes that provided a proof of concept for our genome-host association approach. Our study highlights the polygenic genetic architecture of host adaptation and provides a new application of GWAS in plant pathogens that transcends the limitations imposed by traditional phenotyping methods.

Indexed as

AscomycotaHost-Pathogen InteractionsHost SpecificityPlant DiseasesTriticumChromosome MappingGenome-Wide Association Study

Identifiers

PMID41986618
PMCPMC13652737

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.