ArticleThe Journal of antibiotics2026
(+)-BE-7585A and its derhodinosyl derivative, two cytotoxic 2-thiosugar-containing angucyclines, derived from an actinomycete Amycolatopsis sp. JS6.
Article in The Journal of antibiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
(+)-BE-7585A (1) and its derhodinosyl derivative (2), two rare 2-thiosugar-containing angucyclines, together with their biosynthetic precursor sakyomicin A (3), were isolated from the culture broth of the rare actinomycete Amycolatopsis sp. JS6. Their planar structures were determined by 1D/2D NMR and HRESI-MS data analyses, and the absolute configurations were established by comparison of ECD spectra. Compounds 1 and 2 exhibited weak to modest cytotoxicity against human cervical adenocarcinoma HeLa S3 cells and acute promyelocytic leukemia HL-60 cells, which was much less potent than that of 3, indicating the hydroxy group at C-12b and the substitution at C-5 by the thiodisaccharide moiety of the aglycon may contribute to the cytotoxicity.
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