ArticleScientific reports2026
Major life changes following psychedelic use: A retrospective survey among people using psychedelics naturalistically.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Aspirational autonomy and psychedelic-assisted therapy in advanced cancer: ethical lessons from clinical cases.The oncologist · 2026Article
- Exploring self-reported health behavior change following naturalistic psychedelic use.Journal of health psychology · 2026Article
- Review
- Prevalence, types, and demographic characteristics associated with major life changes following psychedelic use.Scientific reports · 2026Article
- Health-related behavioral changes following the use of psychedelics in naturalistic settings.Preventive medicine reports · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Psychedelic drugs show promise in facilitating a variety of long-term psychological changes, but they may also lead to unexpected major life changes that have not been captured by measures typically used in clinical trials. The Psychedelic-related Major Life Changes Questionnaire (P-MLCQ) was created to assess psychedelic-related major life changes across 10 different domains and evaluated in a sample reporting naturalistic psychedelic use (N = 581). 482/581 participants (82.96%) reported at least one major life change influenced by their psychedelic use (M = 3.29, SD = 2.60), including changes in Goals (53.70%), Values (53.53%), Religion/spirituality (49.05%), Social activities (37.01%), Eating habits/diet (34.08%), Occupation/Line of work (32.36%), Hobbies (29.43%), Political views (14.97%), Sexuality (13.08%), and Marital status/non-marital partner change (12.22%). Major life changes were rated highly positively (M = 4.64, SD = 0.61 on a 5-point scale). There was a positive relationship between frequency of psychedelic use over the last five years and total number of psychedelic-related major life changes (r = 0.34, p < 0.001). Women were 21% more likely than men to report major life changes, whereas age and education-level were negatively related to major life changes. Although our results support that psychedelic use can be followed by major life changes, future research is needed to examine the generalizability of these results in representative samples that are less susceptible to positive bias.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.