Evidence map›Paper›PMID 41986337›Full record

ArticleNature communications2026

PsAvh109 suppresses SA-triggered immunity by mimicking TPL function to disrupt mediator complex assembly.

Xinwei Tan, Yujing Sun, Zhaomei Qi, Yonghui Miao, Zhen Liu, Yiman Wan, Xiaoyuan Hou, Hengjing Li, Wenxiu Li, Yuan Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xinwei Tan *Department of Plant Pathology, College of Plant Protection, Shandong Agricultural University, Taian, China.ORCID 0009-0008-9921-1815
Yujing Sun *Department of Plant Pathology, College of Plant Protection, Shandong Agricultural University, Taian, China.
Zhaomei QiDepartment of Plant Pathology, College of Plant Protection, Shandong Agricultural University, Taian, China.
Yonghui MiaoDepartment of Plant Genetics and breeding, College of Agronomy, Shandong Agricultural University, Taian, China.
Zhen LiuDepartment of Plant Genetics and breeding, College of Agronomy, Shandong Agricultural University, Taian, China.
Yiman WanDepartment of Plant Pathology, College of Plant Protection, Shandong Agricultural University, Taian, China.
Xiaoyuan HouDepartment of Plant Pathology, College of Plant Protection, Shandong Agricultural University, Taian, China.
Hengjing LiDepartment of Plant Pathology, College of Plant Protection, Shandong Agricultural University, Taian, China.
Wenxiu LiDepartment of Plant Pathology, College of Plant Protection, Shandong Agricultural University, Taian, China.
Yuan ChenPeking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences in Weifang, Weifang, China. yuan.chen@pku-iaas.edu.cn.ORCID 0000-0001-6016-5489
Qian XuDepartment of Plant Genetics and breeding, College of Agronomy, Shandong Agricultural University, Taian, China. xuqian@sdau.edu.cn.ORCID 0000-0002-7106-2714
Qunqing WangDepartment of Plant Pathology, College of Plant Protection, Shandong Agricultural University, Taian, China. wangqunqing@sdau.edu.cn.ORCID 0000-0002-3424-8018

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32172049National Natural Science Foundation of China (National Science Foundation of China) 32172387, 31972249Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation) SYS202206Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation) ZR2021YQ20 and ZR2024MC195Shandong Agricultural University (SDAU) SKL81121Shandong Agricultural University (SDAU) SKL81127Taishan Scholar Foundation of Shandong Province tsqn202211093Taishan Scholar Project of Shandong Province No. tscy20221172
6 · The paper itself

Abstract

Pathogens disrupt transcriptional hubs to subvert host immunity, yet the spatiotemporal mechanisms remain enigmatic. Here, we report a pathogen effector interferes with the core eukaryotic transcriptional machinery by acting as a functional mimic of host repressors, deploying this suppression in synchrony with the plant immune rhythm. We discover the Phytophthora sojae nuclear effector directly targets the host Mediator complex. Crucially, PsAvh109 emulates the host repressor TOPLESS (TPL), competitively occupying the Mediator subunit MED21 and locks the MED21-MED6 interaction interface, repressing salicylic acid (SA)-responsive defense genes. Strikingly, PsAvh109 expression is induced by host-derived SA, the very signal displaces TPL from MED21 to activate immunity. This enables the pathogen to release the essential effector PsAvh109 precisely when the host initiates defense, perpetuating transcriptional repression during a critical vulnerability window. Our findings reveal a previously unrecognized strategy where pathogens exploit host signaling dynamics to release effectors that enforce sustained repression of defense programs.

Indexed as

ArabidopsisArabidopsis ProteinsMediator ComplexPhytophthoraPlant DiseasesPlant ImmunityRepressor ProteinsSalicylic AcidGene Expression Regulation, PlantHost-Pathogen InteractionsSignal TransductionArabidopsis ProteinsMediator ComplexRepressor ProteinsSalicylic Acid

Identifiers

PMID41986337
PMCPMC13083866

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.