Evidence map›Paper›PMID 41986233›Full record

ArticleGenes & development2026

KLF18 is a necessary component of the DUX4-initiated transcriptional network and a candidate locus for phenotypic diversity.

Danielle C Hamm, Aidan B O'Donnell, Sean R Bennett, Richard J L F Lemmers, Patrick J van der Vliet, Silvère M van der Maarel, Stephen J Tapscott

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Exit from totipotency in mammals: an epigenetic perspective.Frontiers in cell and developmental biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Danielle C HammHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington 98109, USA.ORCID 0000-0003-2966-7389
Aidan B O'DonnellHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington 98109, USA.
Sean R BennettHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington 98109, USA.
Richard J L F LemmersDepartment of Human Genetics, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.
Patrick J van der VlietDepartment of Human Genetics, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.
Silvère M van der MaarelDepartment of Human Genetics, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.ORCID 0000-0001-8103-711X
Stephen J TapscottHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington 98109, USA; stapscot@fredhutch.org.ORCID 0000-0002-0319-0968

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Wellstone Muscular Dystrophy Specialized Research Center (Seattle)P50AR065139 · NIAMS · UNIVERSITY OF WASHINGTON · PI MICHAEL REGNIER · 2018 to 2026
$15.9M
MYOTONIC DYSTROPHY LOCUS CONTROLR01AR045203 · NIAMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TAPSCOTT, STEPHEN J · 1998 to 2025
$9.4M
NCI NIH HHS P30 CA015704NIAMS NIH HHS P50 AR065139NIAMS NIH HHS R01 AR045203
6 · The paper itself

Abstract

DUX4 initiates the first wave of zygotic genome activation (ZGA) in the human embryo, and its misexpression in skeletal muscle causes facioscapulohumeral muscular dystrophy (FSHD). However, other factors that help regulate ZGA-like transcription in human development and disease are still not fully understood. Here we identify Krüppel-like factor 18 (KLF18) as a component of a DUX4 feed-forward network that is necessary for expression of

Indexed as

Gene Expression Regulation, DevelopmentalGene Regulatory NetworksHomeodomain ProteinsKruppel-Like Transcription FactorsAnimalsChromatinHumansMiceMuscular Dystrophy, FacioscapulohumeralPhenotypeProtein BindingChromatinDUX4L1 protein, humanHomeodomain ProteinsKruppel-Like Transcription FactorsDUX4facioscapulohumeral dystrophyKLF17KLF18variable number of tandem repeatszygotic genome activationβ-solenoid

Identifiers

PMID41986233
PMCPMC13224869

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.