Evidence map›Paper›PMID 41986170›Full record

ReviewBest practice & research. Clinical rheumatology2026

Decoding pain in axial spondyloarthritis: Mechanisms, management, and future directions.

Mohamad Bittar, Yvonne C Lee, Atul Deodhar

Abstract readReview
In one paragraph

Review in Best practice & research. Clinical rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mohamad BittarDivision of Arthritis & Rheumatic Diseases, Oregon Health & Science University, Portland, OR, USA. Electronic address: bittar@ohsu.edu.
Yvonne C LeeDivision of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Atul DeodharDivision of Arthritis & Rheumatic Diseases, Oregon Health & Science University, Portland, OR, USA.

Funding

Mentored Patient-Oriented Research of Novel Mechanisms Linking Pain, Sleep-Wake Patterns, and Autonomic Activity in Rheumatic DiseasesK24AR080840 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Yvonne Claire Lee · 2023 to 2026
$764k
NIAMS NIH HHS K24 AR080840
6 · The paper itself

Abstract

Axial spondyloarthritis (axSpA) is an immune-mediated inflammatory condition that is associated with significant disease burden. While the use of biologic and targeted synthetic disease modifying antirheumatic drugs have led to significant improvements in disease outcomes, a substantial proportion of patients continue to face challenges with pain despite effective control of their inflammatory state. Chronic pain is one of the leading causes of disability and remains an unmet research and clinical need in axSpA. Phenotyping pain is essential to understand the etiology of symptoms and to aid in selecting the appropriate management plan in axSpA. In this review, we aim to highlight the mechanisms of pain, its phenotypes, and novel assessment tools. We also review our approach to managing chronic pain in axSpA and discuss future directions in this field.

Indexed as

Axial SpondyloarthritisChronic PainPain ManagementHumansPain MeasurementAxial spondyloarthritisNeuroimagingPainQuantitative sensory testing

Identifiers

PMID41986170
PMCPMC13610285

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.