ArticleJournal of neurology, neurosurgery, and psychiatry2026
Incidence of cerebral cavernous malformations among adults in Scotland: a prospective, population-based study.
Article in Journal of neurology, neurosurgery, and psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInformation about the incidence of cerebral cavernous malformations (CCM) is sparse and the effect of increasing MRI availability is uncertain. Our objective was to assess the incidence of symptomatic and incidental CCM over time.
methodsThis prospective, population-based study used multiple overlapping sources of case ascertainment to identify all adults aged ≥16 years who were newly diagnosed with CCM using brain MRI or pathology in Scotland between 1 January 1999 and 31 December 2003 or 1 January 2006 and 31 December 2010 inclusive. Crude, age-stratified, sex-stratified and symptomatic versus incidental CCM incidence rates were calculated using Scottish mid-year population estimates.
resultsThe crude incidence for 300 newly diagnosed CCM cases (median age 44 years, 141 (47%) men) was 0.72 (95% CI 0.64 to 0.80) per 100 000 adults per year, with similar rates for men and women. The incidence of symptomatic CCM was higher than that of incidentally detected CCM (0.40 (0.34 to 0.47) versus 0.31 (0.26 to 0.37), p=0.028). Between 1999-2003 and 2006-2010, there were statistically non-significant increases in symptomatic and incidental incidence of CCM (0.36 (0.28 to 0.45) to 0.44 (0.36 to 0.54), p=0.18; 0.30 (0.23 to 0.38) to 0.33 (0.26 to 0.41), p=0.59). The estimated probability of becoming symptomatic for people with asymptomatic CCM was 0.25% (0.22%-0.29%) per year. Overall incidence increased with age, adjusted for year of diagnosis and sex (adjusted incidence rate ratio 1.09 (1.01 to 1.17) per decade increase, p=0.019).
conclusionsThe incidence of symptomatic CCM exceeded that of incidentally discovered CCM; however, no significant change was observed over time. Approximately 1 in 400 people with asymptomatic CCM become symptomatic annually. These findings can help plan healthcare service delivery and research study recruitment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.