ArticleBMJ open2026
LIFE-UP Day audit to monitor implementation of post-intensive care syndrome prevention practices: a multicentre cross-sectional study in Belgian intensive care units.
Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate the feasibility and relevance of the LIFE-UP Day audit, a simple, 1-day benchmarking tool based on the multidisciplinary LIFE-UP bundle (Limit sedation, optimise nutritional Intakes, engage Families, promote Exercise and follow-UP the patients after discharge) and assessing the implementation of postintensive care syndrome (PICS) prevention strategies in daily practice.
designExploratory multicentre cross-sectional audit study.
settingEight Belgian adult intensive care units (ICUs), between April and July 2024.
participantsAll patients present at 08:00 on the audit day and hospitalised for ≥24 hours.
main outcome measuresAn independent nurse collected data on sedation, analgesia, nutrition, family empowerment, physical exercise and post-ICU follow-up. A multidimensional LIFE-UP composite score (raw 0-10 points), normalised to a 5-point scale, was created to quantify adherence to PICS prevention practices based on current recommendations. Feasibility was evaluated through data accessibility, resource needs, cooperation of ICU teams and the ability to complete the audit within 1 day. Relevance was evaluated through adherence to the bundle, assessed by comparing LIFE-UP scores between ICUs. Quantitative results were expressed as median and IQR.
resultsThe audit was tested in 87 patients aged 68 (59-74) years, 9 (5-15.5) days after their admission. The audit was feasible across all ICUs: necessary data were available, resources required were minimal and cooperation was excellent. The LIFE-UP score highlighted significant variability between ICUs (2.5 (1.75-2.75), p<0.001). The lowest-performing domains were nutritional adequacy, family engagement and structured post-ICU follow-up.
conclusionsThe LIFE-UP Day audit proved feasible and provides a first structured framework for benchmarking. Broader implementation will be essential to validate the LIFE-UP score, refine the model and ultimately determine whether it can translate into improved patient and family outcomes.
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