Evidence map›Paper›PMID 41985860›Full record

ArticleEnvironmental research2026

Identifying associations and key early life exposure windows for organophosphate esters and adolescent brain morphometry in the HOME study.

Zheng Ren, Aimin Chen, Jagadeesh Puvvula, Yingying Xu, Ethan Bouche, Antonia M Calafat, Alex D Edmondson, Kristin A Linn, Russell T Shinohara, Maria Ospina and 7 more

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In one paragraph

Article in Environmental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Zheng RenDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, USA; Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.
Aimin ChenDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jagadeesh PuvvulaDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Yingying XuDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Ethan BouchePenn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Antonia M CalafatNational Center for Environmental Health, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
Alex D EdmondsonDepartment of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Environmental & Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Kristin A LinnPenn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Russell T ShinoharaPenn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA, USA.
Maria OspinaNational Center for Environmental Health, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
Zana PercyDepartment of Environmental & Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Ann M VuongDepartment of Epidemiology and Biostatistics, School of Public Health, University of Nevada, Las Vegas, Las Vegas, NV, USA.
Joseph M BraunDepartment of Epidemiology, Brown University, Providence, RI, USA.
Bruce P LanphearFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; Child and Family Research Institute, BC Children's Hospital, Vancouver, BC, Canada.
Kimberly YoltonDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Quy CaoPenn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kim M CecilDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Department of Environmental & Public Health Sciences, College of Medicine, University of Cincinnati, Cincinnati, OH, USA. Electronic address: kim.cecil@cchmc.org.

Funding

Study of Prevalent Neurotoxicants in ChildrenP01ES011261 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI LANPHEAR, BRUCE P · 2001 to 2006
$6.4M
Developmental neurotoxicity of organophosphate and novel brominated flame retardants in childrenR01ES028277 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI CHEN, AIMIN · 2017 to 2022
$3.4M
Impact of pre- and postnatal chemical mixture exposures on child neurobehavior and neuroimagingR01ES033054 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI CHEN, AIMIN · 2021 to 2025
$3.3M
Early life perfluoroalkyl substance exposure & obesity: Mechanisms & phenotypingR01ES025214 · NIEHS · BROWN UNIVERSITY · PI BRAUN, JOSEPH M · 2016 to 2020
$3.1M
Internalizing Behaviors and Neuroimaging Outcomes: Impact of PBDE and PFC ExposuresR01ES027224 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI CECIL, KIM M, YOLTON, KIMBERLY · 2016 to 2020
$3.0M
A Community-Based Trial to Prevent Lead Poisoning and InjuriesR01ES014575 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI YOLTON, KIMBERLY · 2007 to 2011
$2.9M
Longitudinal study of exposure to PBDEs and PFCs and child neurobehaviorR01ES020349 · NIEHS · UNIVERSITY OF CINCINNATI · PI CHEN, AIMIN, LANPHEAR, BRUCE P · 2011 to 2015
$2.9M
Early life organophosphate ester (OPE) exposures and adiposity and cardiometabolic health during adolescenceR01ES033200 · NIEHS · UNIVERSITY OF NEVADA LAS VEGAS · PI Ann Vuong · 2022 to 2026
$2.0M
NIEHS NIH HHS P01 ES011261NIEHS NIH HHS R01 ES014575NIEHS NIH HHS R01 ES020349NIEHS NIH HHS R01 ES025214NIEHS NIH HHS R01 ES027224NIEHS NIH HHS R01 ES028277NIEHS NIH HHS R01 ES033054NIEHS NIH HHS R01 ES033200
6 · The paper itself

Abstract

backgroundOrganophosphate esters (OPEs) can be used as flame retardants and plasticizers in consumer products. Early life exposure may disrupt brain development by modifying brain structure and neurochemistry.

objectivesTo evaluate the associations between gestational and childhood OPE metabolite urinary concentrations and their mixtures with neurobehavioral outcomes, explore the potential mediation of brain structure and neurochemistry, and identify potential windows of susceptibility.

methodsWe employed quantile-based g-computation models to investigate the mixture associations of OPE metabolite concentrations with three distinct categories of outcomes within the HOME Study at age 12 years: 1) magnetic resonance imaging (MRI)-based morphometric measurements; 2) magnetic resonance spectroscopy (MRS)-derived neurochemical concentrations; and 3) neurobehavioral outcomes across four non-overlapping exposure windows: 1) gestational, 2) birth, 3) ages 1-3 years, and 4) ages 5-8 years. We identified outcomes associated with OPE metabolite concentrations. We conducted analyses to evaluate the potential mediation of changes in brain structure and neurochemistry.

resultsUrinary concentrations of the mixture of OPE metabolites were primarily associated with morphometric measurements compared to neurobehavioral outcomes and were seen across all windows investigated before adjusting for multiple comparisons. The OPE metabolite mixture in the 5-8 year window was associated with reduced cortical volume of the pars triangularis, which mediated 27% of the increase in dominant hand drops on the grooved pegboard test before adjusting for multiple comparisons. DISCUSSION: Cortical volume of the pars triangularis may mediate the adverse relationship between OPE metabolite mixture concentrations and adolescent visual motor function during the 5-8-year window.

Indexed as

BrainEnvironmental ExposureEnvironmental PollutantsEstersFlame RetardantsOrganophosphatesPrenatal Exposure Delayed EffectsChildChild, PreschoolFemaleHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMalePregnancyEnvironmental PollutantsEstersFlame RetardantsOrganophosphatesBrain structureChildGrooved pegboardNeurobehaviorNeurochemistryOrganophosphate esters

Identifiers

PMID41985860
PMCPMC13402942

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.