Evidence map›Paper›PMID 41985695›Full record

ArticleOphthalmology2026

Comparative Endophthalmitis Rates in Adult and Pediatric Patients across Various Ophthalmic Procedures: An IRIS® Registry Analysis.

Celine Chaaya, Eric A Goldberg, Connor J Ross, Yi Stephanie Zhang, Joseph D Fahey, Stephanie Zhang, Ryan S Meshkin, Sandra Hoyek, Srujay Pandiri, Tobias Elze and 6 more

Abstract readComparative Study
In one paragraph

Article in Ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Celine ChaayaDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
Eric A GoldbergDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
Connor J RossDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
Yi Stephanie ZhangDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
Joseph D FaheyDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
Stephanie ZhangDepartment of Ophthalmology, University of Arizona College of Medicine-Phoenix, Phoenix, Arizona.
Ryan S MeshkinDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
Sandra HoyekDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
Srujay PandiriDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
Tobias ElzeDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
Alice C LorchDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
John B MillerDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
Joan W MillerDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
Rishi P SinghDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts.
Nimesh A PatelDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts. Electronic address: Nimesh_patel2@meei.harvard.edu.
IRIS® Registry Analytic Center Consortium

Funding

Intramural NIH HHS Z99 EY999999
6 · The paper itself

Abstract

purposeTo evaluate the incidence of endophthalmitis after ophthalmic surgery using a national ophthalmic registry.

designRetrospective clinical cohort study.

participantsPatients in the American Academy of Ophthalmology IRIS® Registry (Intelligent Research in Sight) who underwent ophthalmic surgeries were included in this analysis.

main outcome measureIncidence of endophthalmitis during the first 30 days after surgery.

methodsPediatric and adult patients in the IRIS® Registry with a diagnosis of acute endophthalmitis within 30 days after surgery from 2016 through 2024.

resultsThe study analyzed 17 457 881 procedures. Rates of endophthalmitis varied by procedure. Among adults, the highest incidence occurred after open-globe repair (0.94%; 1 case per 106 procedures). The incidence of endophthalmitis was 0.097% (1 case per 1031 procedures) after vitrectomy for retinal detachment, 0.1% for trabeculectomy (1 case per 1000 procedures), 0.075% for tube shunts (1 case per 1333 procedures), and 0.068% for scleral buckle surgery (1 case per 1459 procedures). The incidence after cataract surgery was 0.038% (1 case per 2652 procedures), 0.039% (1 case per 2551 procedures) after standalone minimally invasive glaucoma surgery, 0.02% (1 case per 5013 procedures) after goniotomy, and 0.011% for strabismus surgery (1 case per 9091 procedures). Among pediatric patients, the incidence of endophthalmitis after open-globe repair was 0.87% (1 case per 115 procedures). The incidence of endophthalmitis was 0.415% (1 case per 675 procedures) after scleral buckle surgery, 0.11% (1 case per 871 procedures) after cataract surgery, 0.084% (1 case per 1190 procedures) after vitrectomy for retinal detachment, and 0.0072% (1 case per 13 884 procedures) after strabismus surgery. The risk of endophthalmitis was significantly higher for pediatric vs. adult patients after cataract surgery (P = 0.014). Endophthalmitis rates after same-date cataract and glaucoma surgery vs. glaucoma surgery alone did not differ significantly.

conclusionsRates of endophthalmitis after ophthalmic surgical procedures are variable, with the highest incidence being open-globe repair. Minimally invasive glaucoma surgery procedures showed comparable infection rates as standard cataract surgery. A higher rate of infection after cataract surgery occurred in pediatric patients when compared with adults. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

EndophthalmitisEye Infections, BacterialOphthalmologic Surgical ProceduresPostoperative ComplicationsRegistriesAdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleHumansIncidenceInfantMaleCataractEndophthalmitisGlaucomaSurgeryVitrectomy

Identifiers

PMID41985695
PMCPMC13508085

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.