ArticleJournal of medicinal chemistry2026
Novel EP2 Antagonist Attenuates Microgliosis and Memory Deficits in Pilocarpine-Induced Status Epilepticus Mice.
Thota Ganesh, Soheila Pourkhodadad, Paola Heman-Bozadas, Raymond Dingledine, Wenyi Wang, Varun Rawat, Nicholas H Varvel, R Jason Herr, Qin Jiang, Graham Johnson
Abstract read
In one paragraphArticle in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Thota GaneshDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, Georgia 30322, United States.ORCID 0000-0002-6163-5590 Soheila PourkhodadadDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, Georgia 30322, United States.
Paola Heman-BozadasDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, Georgia 30322, United States.
Raymond DingledineDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, Georgia 30322, United States.
Wenyi WangDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, Georgia 30322, United States.
Varun RawatDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, Georgia 30322, United States.ORCID 0000-0002-3444-4182 Nicholas H VarvelDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, Georgia 30322, United States.
Qin JiangCuria Global Inc, 24 Corporate Circle, Albany, New York 12203, United States.
Graham JohnsonNuPharmAdvise LLC, Lakeside Dr, Sanbornton, New Hampshire 03269, United States.
Funding
Development of EP2 Receptor Antagonist to Treat Alzheimer's DiseaseU01AG088113 · NIA · EMORY UNIVERSITY · PI Thota Ganesh, Tage Honore · 2024 to 2026
$5.0MOptimization of EP2 Antagonists for Post-Seizure Cognitive DeficitsUH3NS127386 · NINDS · EMORY UNIVERSITY · PI GANESH, THOTA · 2023 to 2024
$1.3MOptimization of EP2 Antagonists for Post-Seizure Cognitive DeficitsUG3NS127386 · NINDS · EMORY UNIVERSITY · PI DINGLEDINE, RAYMOND J, GANESH, THOTA · 2022 to 2022
$678kNIA NIH HHS U01 AG088113NINDS NIH HHS UG3 NS127386NINDS NIH HHS UH3 NS127386
6 · The paper itselfAbstract
EP2 receptors promote neuroinflammation in several central nervous system diseases including status epilepticus (SE). Our laboratory has been optimizing selective small-molecule antagonists for EP2 receptors to determine their functional role in neuropathology and behavioral deficits in SE models, with a goal of developing an EP2 antagonist for clinical use. Through lead-optimization, we identified a novel brain- penetrant compound
Indexed as
GliosisMemory DisordersReceptors, Prostaglandin E, EP2 SubtypeStatus EpilepticusAnimalsHumansMaleMiceMice, Inbred C57BLPilocarpineStructure-Activity RelationshipPilocarpineReceptors, Prostaglandin E, EP2 Subtype
Identifiers
PMID41985077
PMCPMC13181794
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390