Evidence map›Paper›PMID 41984957›Full record

ArticleScience advances2026

Mammalian-like steroidogenesis in plants gives rise to endocrine-mimetic cardenolides.

Menglong Xu, David W Kastner, Weiliang Luo, Fu-Shuang Li, Peter Müller, Yulin Sun, Wentao Huang, Christopher M Glinkerman, Morgan Guempel, Heather J Kulik and 1 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Menglong XuInstitute for Plant-Human Interface, Northeastern University, Boston, MA 02115, USA.ORCID 0000-0002-3177-950X
David W KastnerDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-7766-4249
Weiliang LuoDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0009-0005-6150-2797
Fu-Shuang LiInstitute for Plant-Human Interface, Northeastern University, Boston, MA 02115, USA.
Peter MüllerDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0001-6530-3852
Yulin SunInstitute for Plant-Human Interface, Northeastern University, Boston, MA 02115, USA.
Wentao HuangInstitute for Plant-Human Interface, Northeastern University, Boston, MA 02115, USA.
Christopher M GlinkermanWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.ORCID 0000-0003-0435-7966
Morgan GuempelWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.ORCID 0009-0009-7606-5613
Heather J KulikDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0001-9342-0191
Jing-Ke WengInstitute for Plant-Human Interface, Northeastern University, Boston, MA 02115, USA.ORCID 0000-0003-3059-0075

Funding

Revealing Nature's Blueprints for Single-Site Catalysis of C-H Activation with First-principles Modeling and Machine LearningR35GM152027 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Heather J. Kulik · 2024 to 2026
$1.2M
NIGMS NIH HHS R35 GM152027
6 · The paper itself

Abstract

Steroid hormones are central regulators of eukaryotic physiology, yet their signaling pathways are also exploited as key targets in cross-kingdom endocrine interference. Among them, cardenolides are steroid hormones in mammals that target sodium-potassium adenosine triphosphatase (Na

Indexed as

CardenolidesPlantsSteroidsAnimalsHydroxylationMammalsCardenolidesSteroids

Identifiers

PMID41984957
PMCPMC13082332

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.