ArticlePloS one2026
Spatial and temporal patterns of SARS-CoV-2 infection in uMgungundlovu, KwaZulu-Natal, South Africa.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundInvestigating the spatial distribution of SARS-CoV-2 at a local level and describing the pattern of disease occurrence can be used as the basis for efficient prevention and control measures. This research project aims to utilize geospatial analysis to understand the distribution patterns of SARS-CoV-2 infection and its relationship with certain co-existing factors in uMgungundlovu district, KwaZulu-Natal.
methodsSpatial characteristics of SARS-CoV-2 were investigated over the first four waves of transmission using ESRI ArcGIS Pro v2.0, including Local Indicators of Spatial Association (LISA) with Moran's "I" as the measure of spatial autocorrelation; and Kernel Density Estimation (KDE). In implementing temporal analysis, time series analysis using the Python Seaborn library was used, with separate modelling carried out for each wave.
resultsStatistically significant SARS-CoV-2 incidence rates were noted across age groups with p-values = 0.0000. Statistically significant clustering was evident in wave 1 and wave 3 (Moran's I respectively: wave 1-0.096; wave 2-0.023; wave 3-0.039; wave 4-0.023). The KDE (Highest density of cases: wave 1: 25.0001-50.0, wave 2: 25.0001-50.0, wave 3: 100.001-150.0, wave 4: 50.0001-100.0). Temporal analysis showed more fluctuation at the beginning of each wave with less fluctuation in daily identified cases within the middle to end of each wave.
conclusionA Geospatial approach of analysing infectious disease transmission is proposed to guide control efforts (e.g., testing/tracing and vaccine rollout) for populations at higher vulnerability. Additionally, the nature and configuration of the social and built environment may be associated with increased infection. However, locally specific empirical research is required to assess other relevant factors associated with increased infection.
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