Evidence map›Paper›PMID 41984884›Full record

ArticlePloS one2026

Low FXIII activity levels in patients with vascular anomalies, not in patients with trauma-induced coagulopathy.

Hiroaki Otsubo, Tsuguaki Terashima, Mai Terashima, Siqiang Gao, Mika Ogawa, Hidefumi Kato, Kyosuke Takeshita, Shohei Mizuno, Satsuki Murakami, Akiyoshi Takakmi and 4 more

Abstract read
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Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hiroaki OtsuboDepartment of Clinical Laboratory, Aichi Medical University, Nagakute, Aichi, Japan.
Tsuguaki TerashimaDepartment of Emergency and Critical Care Medicine, Aichi Medical University, Nagakute, Aichi, Japan.
Mai TerashimaDepartment of Clinical Laboratory, Aichi Medical University, Nagakute, Aichi, Japan.
Siqiang GaoDepartment of Blood Transfusion, Aichi Medical University, Nagakute, Aichi, Japan.
Mika OgawaDepartment of Clinical Laboratory, Aichi Medical University, Nagakute, Aichi, Japan.
Hidefumi KatoDepartment of Blood Transfusion, Aichi Medical University, Nagakute, Aichi, Japan.
Kyosuke TakeshitaDepartment of Clinical Laboratory, Saitama Medical Center, Kawagoe, Saitama, Japan.
Shohei MizunoDepartment of Hematology, Aichi Medical University, Nagakute, Aichi, Japan.
Satsuki MurakamiDepartment of Hematology, Aichi Medical University, Nagakute, Aichi, Japan.
Akiyoshi TakakmiDepartment of Hematology, Aichi Medical University, Nagakute, Aichi, Japan.ORCID https://orcid.org/0000-0002-1822-9976
Katsuhiko MatsuyamaDepartment of Cardiac Surgery, Aichi Medical University, Nagakute, Aichi, Japan.
Hiroshi FurukawaDepartment of Plastic and Reconstructive Surgery, Aichi Medical University, Nagakute, Aichi, Japan.
Eizo WatanabeDepartment of Emergency and Critical Care Medicine, Aichi Medical University, Nagakute, Aichi, Japan.ORCID https://orcid.org/0000-0001-6731-909X
Takayuki NakayamaDepartment of Clinical Laboratory, Aichi Medical University, Nagakute, Aichi, Japan.ORCID https://orcid.org/0000-0003-2389-2542

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with localized intravascular coagulopathy (LIC) related to vascular anomalies occasionally suffer from hemorrhage and delayed wound healing, presumably due to consumptive reduction of fibrinogen and platelets. However, LIC patients with normal levels of platelets and fibrinogen can be hemorrhagic for unknown reasons. These facts led us to hypothesize that factor XIII (FXIII) is decreased since FXIII plays an important role in hemostasis, tissue repair, and wound healing. We collected plasma from 17 patients with LIC (9 with aneurysm, 8 with vessel malformation) and 7 patients with trauma-induced coagulopathy (TIC), which showed a fibrinolytic phenotype similar to LIC, and measured FXIII levels. FXIII levels were considerably decreased (7-53%, mean 29.4%) in LIC patients. 13 of 17 patients showed bleeding tendency even though DIC scores were low. However, FXIII levels were only slightly decreased (39-98%, mean 67.4%) in TIC patients. We also investigated the correlation between FXIII activity and coagulation parameters. FXIII activity most strongly correlated with fibrinogen content (R = 0.882, P < 0.001) in LIC patients. FXIII levels below 50% were observed when fibrinogen was less than 200 mg/dL. Based on these findings, we successfully treated two LIC patients with FXIII concentrates. Decreased FXIII activity was specific to LIC, not TIC. Testing for FXIII activity should be considered in LIC patients even with normal fibrinogen levels, who are scheduled to undergo any invasive procedure, since FXIII supplementation is occasionally required for them.

Indexed as

Blood Coagulation DisordersFactor XIIIVascular MalformationsWounds and InjuriesAdultAgedFemaleFibrinogenHumansMaleMiddle AgedYoung AdultFactor XIIIFibrinogen

Identifiers

PMID41984884
PMCPMC13082649

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.