Evidence map›Paper›PMID 41984830›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Uncovering mitochondrial defects in photoreceptors opens therapeutic opportunities for Stargardt disease.

Simona Brillante, Mariagrazia Volpe, Anna Diana, Santiago Negueruela, Marta Molinari, Rosa Saurino, Eva Cipollaro, Elena Polishchuk, Erika Tenderini, Carla Damiano and 8 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Simona BrillanteTelethon Institute of Genetics and Medicine, Pozzuoli 80078, Italy.ORCID 0000-0003-0481-1997
Mariagrazia VolpeTelethon Institute of Genetics and Medicine, Pozzuoli 80078, Italy.
Anna DianaTelethon Institute of Genetics and Medicine, Pozzuoli 80078, Italy.ORCID 0009-0006-3367-8899
Santiago NegueruelaTelethon Institute of Genetics and Medicine, Pozzuoli 80078, Italy.
Marta MolinariTelethon Institute of Genetics and Medicine, Pozzuoli 80078, Italy.ORCID 0000-0003-3252-2789
Rosa SaurinoTelethon Institute of Genetics and Medicine, Pozzuoli 80078, Italy.
Eva CipollaroTelethon Institute of Genetics and Medicine, Pozzuoli 80078, Italy.ORCID 0009-0002-6381-5664
Elena PolishchukTelethon Institute of Genetics and Medicine, Pozzuoli 80078, Italy.
Erika TenderiniTelethon Institute of Genetics and Medicine, Pozzuoli 80078, Italy.ORCID 0000-0002-4073-8259
Carla DamianoTelethon Institute of Genetics and Medicine, Pozzuoli 80078, Italy.ORCID 0000-0001-8833-6112
Patrizia TornabeneTelethon Institute of Genetics and Medicine, Pozzuoli 80078, Italy.
Roman PolishchukTelethon Institute of Genetics and Medicine, Pozzuoli 80078, Italy.ORCID 0000-0002-7698-1955
Giancarlo ParentiTelethon Institute of Genetics and Medicine, Pozzuoli 80078, Italy.
Antonietta TaralloTelethon Institute of Genetics and Medicine, Pozzuoli 80078, Italy.
Sandro BanfiTelethon Institute of Genetics and Medicine, Pozzuoli 80078, Italy.
Ivana TrapaniTelethon Institute of Genetics and Medicine, Pozzuoli 80078, Italy.ORCID 0000-0002-3134-2973
Sabrina CarrellaBiology and Evolution of Marine Organisms Department, Stazione Zoologica Anton Dohrn, Naples 80121, Italy.
Alessia IndrieriTelethon Institute of Genetics and Medicine, Pozzuoli 80078, Italy.ORCID 0000-0002-2325-0913

Funding

BrightFocus Foundation (BFF) M2020184Fondazione Telethon (FT) TGM22MT01Ministero dell'Università e della Ricerca (MUR) PRIN2020 grant 2020XBCMHJ
6 · The paper itself

Abstract

Stargardt disease type 1 (STGD1) is the most common hereditary macular degeneration. It is caused by mutations in

Indexed as

Macular DegenerationMitochondriaPhotoreceptor Cells, VertebrateStargardt DiseaseAnimalsATP-Binding Cassette TransportersGTP PhosphohydrolasesHumansMiceMice, KnockoutMicroRNAsRetinal Pigment EpitheliumAbca4 protein, mouseATP-Binding Cassette TransportersGTP PhosphohydrolasesMicroRNAsOpa1 protein, mousemicroRNAmiR-181a/bmitochondriaphotoreceptorsStargardt disease

Identifiers

PMID41984830
PMCPMC13099569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.