Evidence map›Paper›PMID 41984822›Full record

ArticleRheumatology (Oxford, England)2026

Development of structural damage in the spine in patients with PsA: findings from a longitudinal cohort study.

Fadi Kharouf, Pankti Mehta, Virginia Carrizo Abarza, Shangyi Gao, Daniel Pereira, Ngai Chow, Dafna D Gladman, Vinod Chandran, Denis Poddubnyy

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In one paragraph

Article in Rheumatology (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Fadi KharoufGladman Krembil Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada.ORCID 0000-0002-3540-0341
Pankti MehtaGladman Krembil Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada.
Virginia Carrizo AbarzaGladman Krembil Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada.
Shangyi GaoGladman Krembil Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada.
Daniel PereiraGladman Krembil Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada.
Ngai ChowGladman Krembil Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada.
Dafna D GladmanGladman Krembil Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada.
Vinod ChandranGladman Krembil Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada.
Denis PoddubnyyGladman Krembil Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada.

Funding

Krembil Foundation and the Schroeder Arthritis Institute
6 · The paper itself

Abstract

objectivesThis study aimed to examine associations between disease activity/severity markers across multiple PsA domains and structural damage development in the spine in a large longitudinal cohort.

methodsWe analysed patients from a prospective longitudinal PsA cohort and evaluated structural damage in the spine by assessing the development of new syndesmophytes (a binary outcome) on radiographs of the cervical and lumbar spine. We used Cox regression to examine the association between syndesmophyte development and disease activity and severity variables, including nail involvement, PASI, swollen joint count, SPARCC enthesitis score, dactylitis, cDAPSA, modified Steinbrocker score, radiographic sacroiliitis score (range 0-8), BASDAI, ESR and CRP. Separate multivariable models were conducted and adjusted for age, sex, PsA duration, BMI, smoking status, decade of observation, HLA-B*27, HLA-A*29, NSAID use and, where applicable, radiographic sacroiliitis score and b/tsDMARD use.

resultsAmong 1584 PsA patients (median age 45), 218 (13.8%) had syndesmophytes at baseline (clinic entry). Median follow-up was 8.5 years [IQR: 4.4-14.3]. Among 922 patients without baseline syndesmophytes who underwent repeat radiographs, 166 (18.0%) developed new syndesmophytes, with a median time to development of 5.8 years [IQR: 2.4-9.9]. The incidence of new syndesmophytes appeared to decline in more recent calendar years. In multivariable models, higher ESR (HR 1.02, 95% CI 1.01-1.03) and higher radiographic sacroiliitis score (HR 1.19, 95% CI 1.07-1.32) were associated with syndesmophyte development.

conclusionSyndesmophytes developed in approximately one-fifth of patients with PsA during long-term follow-up. Systemic inflammation and radiographic sacroiliitis are major, independent predictors of spinal structural damage.

Indexed as

Arthritis, PsoriaticCervical VertebraeLumbar VertebraeSpineAdultDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesRadiographySeverity of Illness IndexoutcomesPsAsacroiliitissyndesmophytes

Identifiers

PMID41984822
PMCPMC13131228

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.