ArticleJournal of the American Chemical Society2026
Catalytic Enantioselective Elimination of Cyclobutanols.
Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
Brønsted acid-mediated elimination of alcohols is a fundamental transformation in organic chemistry, yet its application in enantioselective catalysis remains largely unexplored. Here, we report a catalytic, enantioselective elimination of cyclobutanols and their trichloroacetimidate derivatives that afford cyclobutenes bearing all-carbon quaternary stereocenters. Mechanistic studies revealed that a chiral Brønsted acid catalyst mediates concerted, enantioselective elimination of cyclobutanols, whereas their trichloroacetimidates undergo stepwise elimination via a catalyst-substrate covalent intermediate. This research lays the foundation for further investigations of enantioselective elimination reactions.
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