ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Fibronectin1-Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
16 authors.
Funding
Abstract
Novel object recognition (NOR), referring to the cognitive ability to differentiate familiar/novel objects, is a fundamental cognitive function essential for daily life. However, the mechanisms underlying the encoding of novel preference information remain incompletely understood. Here, we demonstrate that the fibronectin1-expressing subiculum-entorhinal circuits selectively govern NOR retrieval. Subicular pyramidal neurons are able to differentiate between familiar and novel objects, and bidirectionally regulate the retrieval of NOR. At the circuit level, subicular-entorhinal projections, rather than those targeting the anterior nucleus of thalamus, mammillary bodies or retrosplenial cortex, encode novel object preference and regulate NOR retrieval. Importantly, fibronectin1 is identified as a key functional molecular component expressing within this glutamatergic circuit, gates neuronal excitability by regulating the large conductance Ca
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