Trial reportEpilepsia2026
Rehabilitation of cognition and psychosocial well-being in epilepsy: Results of a randomized waiting list-controlled trial.
Trial report in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveLimited evidence supports the use of cognitive and psychosocial rehabilitation programs for people with epilepsy (PWE). We assessed the effects of a newly designed cognitive and psychological counseling intervention on patient-reported and neuropsychological outcomes in a mixed sample of PWE.
methodsSeventy adult PWE (57.1% female, mean age = 35.9 ± 11.7 years, 57.1% with focal epilepsy) were randomized (1:1) to either an early intervention group (EIG) or a waiting list for a late intervention group (LIG). The intervention consisted of six individual and two group counseling sessions incorporating psychoeducation, cognitive training, coping strategies, and mindfulness. Both groups were assessed at baseline and 4 and 16 weeks. Primary endpoints were quality of life (Patient-Weighted Quality of Life in Epilepsy 31-item inventory [QOLIE-31-P]) and delayed verbal and visual recall at 4 weeks; secondary endpoints included symptoms of anxiety (Generalized Anxiety Disorder seven-item scale), depression (Neurological Disorders Depression Inventory in Epilepsy), and stigma. Linear mixed models with maximum likelihood estimation were used for repeated measures analysis.
resultsFollow-up data were available for 66 participants (94.3%) at 4 weeks and 61 (87.1%) at 16 weeks. The EIG showed significant improvements on the QOLIE compared with the LIG (group by time interaction p = .006), which were maintained at both follow-ups. Anxiety symptoms were also significantly reduced in the EIG (group by time interaction p = .006). These effects were observed in both focal and generalized epilepsy. No significant group differences were found for delayed verbal or visual recall over time. However, greater long-term forgetting on the word list task was observed in the LIG at 4 weeks. No significant changes were detected for symptoms of depression or perceived stigma. SIGNIFICANCE: An 8-week cognitive and psychosocial rehabilitation program improved quality of life and reduced anxiety in PWE, with effects sustained for up to 16 weeks. Cognitive benefits were limited, with a possible transient effect on long-term verbal recall. These findings support the use of rehabilitation interventions to enhance patient-reported outcomes across epilepsy subtypes.
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