Evidence map›Paper›PMID 41984425›Full record

ArticleBioMed research international2026

Induction of Apoptosis in Colorectal Cancer Cells by Zinc Oxide Nanoparticles Extracted From Lactiplantibacillus plantarum With Gene Expression Control of Apoptosis-Related Genes.

Mohammadreza Azimi, Anoosh Eghdami, Bahram Keyvani, Ramin Cheraghali

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Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mohammadreza AzimiDepartment of Biochemistry, Medical Faculty, Saveh Branch, Islamic Azad University, Saveh, Iran, azad.ac.ir.ORCID https://orcid.org/0000-0001-8490-2500
Anoosh EghdamiDepartment of Biochemistry, Medical Faculty, Saveh Branch, Islamic Azad University, Saveh, Iran, azad.ac.ir.ORCID https://orcid.org/0000-0002-4833-8495
Bahram KeyvaniDepartment of Biochemistry, Medical Faculty, Saveh Branch, Islamic Azad University, Saveh, Iran, azad.ac.ir.
Ramin CheraghaliDepartment of Biochemistry, Medical Faculty, Saveh Branch, Islamic Azad University, Saveh, Iran, azad.ac.ir.ORCID https://orcid.org/0000-0002-1133-5098

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer is the third leading cause of cancer death worldwide. Zinc oxide nanoparticles (ZnO NPs) have garnered attention as potential anticancer agents in cancer therapy research. Synthesis of metal nanoparticles using beneficial bacteria is considered one of the most effective methods for cancer treatment, with minimal side effects. This study is aimed at synthesizing ZnO nanoparticles from Lactiplantibacillus plantarum biofilm and investigate their impact on cell division and apoptosis-related gene expression in colorectal epithelial cancer cells (HT-29) under laboratory conditions. After isolating and validating ZnO nanoparticles in the L. plantarum biofilm, HT-29 cells were cultured with different concentrations of zinc oxide nanoparticles for 24 h, and MTT was used to determine IC

Indexed as

ApoptosisColorectal NeoplasmsGene Expression Regulation, NeoplasticLactiplantibacillus plantarumMetal NanoparticlesNanoparticlesZinc OxideAntineoplastic AgentsBiofilmsCell SurvivalHT29 CellsHumansAntineoplastic AgentsZinc OxideapoptosisHK2Lactiplantibacillus plantarumnanoparticlepkm2zinc oxide

Identifiers

PMID41984425
PMCPMC13082214

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.