Evidence map›Paper›PMID 41984400›Full record

ArticleDrug delivery and translational research2026

A dual-function rebamipide cubogel for enhanced ocular penetration and tear film restoration: optimization, safety, and in-vivo evaluation.

Mayar Salama, Islam M Adel, Randa Tag, Ahmed R Fares

Abstract read
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In one paragraph

Article in Drug delivery and translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mayar SalamaDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt. mayar.salama@pharma.cu.edu.eg.ORCID http://orcid.org/0009-0005-7187-3161
Islam M AdelDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.ORCID http://orcid.org/0000-0002-0347-0513
Randa TagDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.
Ahmed R FaresDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.

Funding

Ellebedy Fellowship for Young Scientists EF3/2024/4.
6 · The paper itself

Abstract

Dry eye disease is a troublesome multifactorial ocular condition, affecting 5-50% of the population. Rebamipide is a mucin secretagogue with anti-inflammatory properties used for dry eye management, however, its efficacy is limited due to its poor aqueous solubility and low tissue permeation. This study aimed to formulate and optimize rebamipide-loaded cubosomes incorporated into a carboxymethyl cellulose gel to achieve a dual action of sustained drug release and enhanced corneal penetration. The proposed cubosomes were prepared via hot melt emulsification technique and optimized applying a 3

Indexed as

CubogelDry eye diseaseGriess assayOcular drug deliveryRebamipideSchirmer’s test

Identifiers

PMID41984400

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.