ArticleJournal of neuro-oncology2026
Alterations in cerebral iron deposition in low-grade glioma-related epilepsy.
Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the patterns of iron deposition using quantitative susceptibility mapping (QSM) and their relationship with epilepsy duration in patients with low-grade glioma-related epilepsy (GRE).
methodsThis retrospective study enrolled 59 patients with low-grade gliomas, who were subsequently stratified into an epilepsy group and a non-epilepsy group. QSM was employed to quantify iron content in these patients. Regions of interest (ROIs) were defined as the tumor region, cortical regions, and deep gray matter nuclei. The mean magnetic susceptibility values within each ROI were calculated and compared between the two groups. Furthermore, the correlation between these values and epilepsy duration was analyzed in the epilepsy group.
resultsAnalysis of the 59 patients revealed that, compared to those without epilepsy, patients with epilepsy had significantly higher magnetic susceptibility values in the tumor region (p = 0.018), frontal cortex (p = 0.037), precentral gyrus (p = 0.003), and parietal cortex (p = 0.037). Although a positive correlation was observed in the epilepsy group between putamen susceptibility and epilepsy duration (r² = 0.172, p = 0.023), it did not retain statistical significance after adjustment for age.
conclusionIron deposition in the tumor region and certain cortical areas is higher in patients with epilepsy than in non-epilepsy patients. However, iron deposition demonstrates no significant correlation with the duration of epilepsy.
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