Evidence map›Paper›PMID 41984311›Full record

ArticleAdvances in therapy2026

Adverse Childhood Experiences and Disease Activity Are Associated with Post-Traumatic Stress Symptoms in Crohn's Disease.

Giorgia Spagnolo, Daniele Ferrarese, Federica Di Vincenzo, Jacopo Iaccarino, Marco Murgiano, Michele Vecchione, Guglielmo Sicilia, Daniele Napolitano, Antonio Maria D'Onofrio, Antonio Gasbarrini and 3 more

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Article in Advances in therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Giorgia Spagnolo *Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
Daniele Ferrarese *Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
Federica Di VincenzoDipartimento Universitario di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy. federica.divincenzo01@icatt.it.ORCID http://orcid.org/0000-0002-5347-7641
Jacopo IaccarinoDipartimento Universitario di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
Marco MurgianoDipartimento Universitario di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
Michele VecchioneDepartment of Social and Developmental Psychology, Sapienza University of Rome, Rome, Italy.
Guglielmo SiciliaDipartimento Universitario di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
Daniele NapolitanoSITRA - Scientific Direction- Fondazione Policlinico Gemelli IRCCS, Rome, Italy.
Antonio Maria D'OnofrioDipartimento Universitario di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
Antonio GasbarriniDipartimento Universitario di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
Giovanni CamardeseDepartment of Neuroscience, Section of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.
Daniela Pia Rosaria ChieffoClinical Psychology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Franco ScaldaferriDipartimento Universitario di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCrohn's disease (CD) is a chronic inflammatory bowel disease associated with a substantial psychological burden, including post-traumatic stress symptoms (PTSS). However, PTSS do not develop in all patients, suggesting individual vulnerability factors. Adverse childhood experiences (ACEs) are a transdiagnostic risk factor for stress-related psychopathology and may influence psychological responses to chronic disease. We examined whether ACEs moderate the relationship between clinical disease activity and PTSS in patients with CD.

methodsIn this cross-sectional study, outpatients with CD completed self-report measures assessing PTSS and ACEs. Clinical disease activity was assessed using the Harvey-Bradshaw Index. Data were analyzed using Pearson correlation coefficients and hierarchical moderated regression analyses.

resultsA total of 161 outpatients with CD were included. Clinically significant PTSS were observed in 32.1% of the sample. Disease activity was positively associated with PTSS (r = .33, p < .01), as was cumulative ACE exposure (r = .38, p < .01). In regression analyses, both disease activity (β = .22, p = .013) and ACEs (β = .35, p < .001) independently predicted PTSS, whereas disease duration was inversely associated (β =  - .19, p = .047). A significant interaction between disease activity and ACEs emerged (ΔR

conclusionEarly-life adversity appears to increase vulnerability to PTSS in the context of active CD. ACE-informed assessments may help identify patients at higher psychological risk and guide trauma-informed clinical care.

Indexed as

Adverse Childhood ExperiencesCrohn DiseaseStress Disorders, Post-TraumaticAdolescentAdultCross-Sectional StudiesFemaleHumansMaleMiddle AgedRisk FactorsSelf ReportSeverity of Illness IndexAdverse childhood experiencesCrohn’s diseaseGut–brain axisPost-traumatic stress symptomsPsychological distress

Identifiers

PMID41984311
PMCPMC13222271

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.