Evidence map›Paper›PMID 41984227›Full record

Trial reportPediatric surgery international2026

Modified enhanced recovery after surgery protocol for pediatric complicated appendicitis in a Mexican tertiary hospital: a randomized clinical trial.

Ana Beatriz Calderón-Alvarado, Gabriela Ambriz-González, Clotilde Fuentes-Orozco, Alejandro Rubén Villaseñor-Rodriguez, Jazmín Montserrat Guzmán-Diaz, Isaac Jasso-García, Roberto Carlos García-Romero, Samantha Emily González-Muñoz, Guadalupe Castillo-Cardiel, Gabino Cervantes-Guevara and 6 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Pediatric surgery international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05511194 (Safety and Efficacy of Enhanced Recovery After Surgery Therapeutic Protocol for Complicated Appendicitis in Children), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05511194 naunknown statusnot on this map

Safety and Efficacy of Enhanced Recovery After Surgery Therapeutic Protocol for Complicated Appendicitis in Children

TypeinterventionalSponsorInstituto Mexicano del Seguro SocialRan2022 to 2023Enrolled40ConditionsEnhanced Recovery After Surgery, Appendicitis, Children, OnlyArmsEnhanced Recovery After Surgery therapeutic protocol, Conventional management
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ana Beatriz Calderón-AlvaradoDepartment of Pediatric Surgery, High Specialty Medical Unit, Pediatric Hospital of the National Medical Center of the West, Mexican Social Security Institute, Av. Belisario Domínguez 735, Independencia Oriente, 44340, Guadalajara, Jalisco, México.
Gabriela Ambriz-González *Department of Pediatric Surgery, High Specialty Medical Unit, Pediatric Hospital of the National Medical Center of the West, Mexican Social Security Institute, Av. Belisario Domínguez 735, Independencia Oriente, 44340, Guadalajara, Jalisco, México. ggaby03@yahoo.com.ORCID http://orcid.org/0000-0003-4011-6078
Clotilde Fuentes-Orozco *Biomedical Research Unit 02, National Medical Center of the West, Mexican Social Security Institute, Av. Belisario Domínguez 999, Guadalajara, Jalisco, México. clotilde.fuentes@gmail.com.ORCID http://orcid.org/0000-0001-6230-8359
Alejandro Rubén Villaseñor-RodriguezBiomedical Research Unit 02, National Medical Center of the West, Mexican Social Security Institute, Av. Belisario Domínguez 999, Guadalajara, Jalisco, México.
Jazmín Montserrat Guzmán-DiazBiomedical Research Unit 02, National Medical Center of the West, Mexican Social Security Institute, Av. Belisario Domínguez 999, Guadalajara, Jalisco, México.
Isaac Jasso-GarcíaBiomedical Research Unit 02, National Medical Center of the West, Mexican Social Security Institute, Av. Belisario Domínguez 999, Guadalajara, Jalisco, México.
Roberto Carlos García-RomeroBiomedical Research Unit 02, National Medical Center of the West, Mexican Social Security Institute, Av. Belisario Domínguez 999, Guadalajara, Jalisco, México.
Samantha Emily González-MuñozBiomedical Research Unit 02, National Medical Center of the West, Mexican Social Security Institute, Av. Belisario Domínguez 999, Guadalajara, Jalisco, México.
Guadalupe Castillo-CardielBiomedical Research Unit 02, National Medical Center of the West, Mexican Social Security Institute, Av. Belisario Domínguez 999, Guadalajara, Jalisco, México.
Gabino Cervantes-GuevaraDepartment of Wellbeing and Sustainable Development, Centro Universitario del Norte, University of Guadalajara, Colotlán, Guadalajara, Jalisco, México.
Enrique Cervantes-PérezDepartment of Internal Medicine, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, México.
Sol Ramírez-OchoaDepartment of Internal Medicine, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, México.
Alejandro González-OjedaFaculty of Medicine, Universidad de Colima, Colima, Jalisco, México.
Sergio Jiram Vázquez-SánchezBiomedical Research Unit 02, National Medical Center of the West, Mexican Social Security Institute, Av. Belisario Domínguez 999, Guadalajara, Jalisco, México.
Andrea Socorro Álvarez-VillaseñorAuxiliary Medical Coordination of Health Research, Mexican Institute of Social Security, La Paz, BCS, México.
Hannia Betzabeth Moya-AmbrizDepartment of Surgical Techniques Laboratory Faculty of Medicine, Universidad de Guadalajara, Guadalajara, Jalisco, México.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesAcute appendicitis often requires emergency surgery and leads to prolonged length of hospital stay (LOS). Enhanced recovery after surgery (ERAS) protocol promotes rapid recovery and shorter hospital stays, revolutionizing the management of pediatric surgery. The aim of the study was to evaluate the safety and efficacy of an ERAS therapeutic protocol for postoperative management in children with complicated appendicitis compared with conventional treatment.

methodsA single-blind, randomized controlled clinical trial was performed on patients diagnosed with complicated appendicitis between July 1 and December 31, 2022. Patients were randomly assigned to either the control group, which received conventional triple antibiotic treatment and oral feeding after restoring intestinal transit, or ERAS group, which received double antibiotic regimen, nausea prevention, and oral feeding 6 h after appendectomy. We analyzed LOS and the incidence of postoperative morbidity. The trial was registered at the Local Health Research and Ethics Committee (identifier R-2022-1302-056) and ClinicalTrials.gov ( https://www.clinicaltrials.gov/ ; identifier NCT05511194; 01/31/2023).

resultsForty patients, 70% male, average age 8 years, were included. Twenty patients received ERAS protocol management, while 20 received conventional management. The ERAS group had a shorter average LOS (3.15 days vs. 5.20 days, p = 0.001). Postoperative minor morbidities were similar between the groups.

conclusionThe modified ERAS protocol reduced LOS and did not increase postoperative morbidity.

Indexed as

AppendectomyAppendicitisEnhanced Recovery After SurgeryAnti-Bacterial AgentsChildChild, PreschoolClinical ProtocolsFemaleHumansLength of StayMaleMexicoPostoperative ComplicationsSingle-Blind MethodTertiary Care CentersTreatment OutcomeAnti-Bacterial AgentsappendicitisERAS protocollength of hospital staymorbiditypediatrics

Identifiers

PMID41984227

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.