Evidence map›Paper›PMID 41984207›Full record

ArticlePediatric surgery international2026

Genetic association analysis of lnc-AMFR-1:1 rs4784659 C > T and neuroblastoma susceptibility in Chinese pediatric patients.

Tianli Feng, Yuling Su, Chunlei Zhou, Xinxin Zhang, Jiabin Liu, Wenli Zhang, Jing He, Xinjiang Huang

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Article in Pediatric surgery international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Tianli Feng *Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China.
Yuling Su *Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China.
Chunlei Zhou *Department of Pathology, Children's Hospital of Nanjing Medical University, Nanjing, 210008, Jiangsu, China.
Xinxin ZhangDepartment of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China.
Jiabin LiuDepartment of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China.
Wenli ZhangDepartment of Genetics and Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China.
Jing HeDepartment of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China. hejing198374@gmail.com.ORCID https://orcid.org/0000-0002-1954-2892
Xinjiang HuangDepartment of Genetics and Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China. xinjiangwong123@163.com.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515220053Guangzhou Municipal Science and Technology Project 2025A04J4537National Natural Science Foundation of China 32300473
6 · The paper itself

Abstract

backgroundNeuroblastoma, a neuroendocrine tumor of the sympathetic ganglia, is the leading solid extracranial malignancy in children. The lnc-AMFR-1:1 rs4784659 polymorphism in long noncoding RNA (lncRNA) has been reported to be associated with susceptibility to several cancers, but its role in neuroblastoma remains unclear.

methodsWe studied 402 patients with neuroblastoma and 473 cancer-free controls from Jiangsu Province to assess the association between lnc-AMFR-1:1 rs4784659 C > T and neuroblastoma susceptibility using odds ratios (ORs) and 95% confidence intervals (CIs).

resultsAnalysis under any of the genetic models tested failed to reveal a significant link between the rs4784659 C > T polymorphism and neuroblastoma risk (CT vs. CC: adjusted OR = 0.96, 95% CI = 0.73–1.28, P = 0.799; TT vs. CC: adjusted OR = 1.40, 95% CI = 0.77–2.53, P = 0.273; TT/CT vs. CC: adjusted OR = 1.01, 95% CI = 0.77–1.33, P = 0.924; TT vs. CC/CT: adjusted OR = 1.41, 95% CI = 0.79–2.54, P = 0.245). Moreover, stratified analysis revealed no significant associations.

conclusionThis study provided no evidence of an association between the lnc-AMFR-1:1 rs4784659 C > T polymorphism and the risk of neuroblastoma. These findings warrant validation in larger and more diverse populations.

Indexed as

Genetic Predisposition to DiseaseNeuroblastomaRNA, Long NoncodingCase-Control StudiesChildChild, PreschoolChinaEast Asian PeopleFemaleHumansInfantMalePolymorphism, Single NucleotideRNA, Long Noncodinglnc-AMFR-1:1NeuroblastomaPolymorphismSusceptibility

Identifiers

PMID41984207

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