Evidence map›Paper›PMID 41984139›Full record

ArticleClinical and experimental nephrology2026

Association between serum lactate dehydrogenase level and renal outcome in patients with advanced chronic kidney disease without diabetes mellitus.

Yoshihiro Nakamura, Shimon Kurasawa, Takahiro Imaizumi, Terumasa Hayashi, Ichiei Narita, Kenichiro Tanabe, Satoshi Morita, Yoshiharu Tsubakihara, Enyu Imai, Tadao Akizawa and 1 more

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In one paragraph

Article in Clinical and experimental nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yoshihiro NakamuraDepartment of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Aichi, Japan.
Shimon KurasawaDepartment of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Aichi, Japan.
Takahiro ImaizumiDepartment of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Aichi, Japan.
Terumasa HayashiDepartment of Kidney Disease and Hypertension, Osaka General Medical Center, Osaka, Japan.
Ichiei NaritaDivision of Clinical Nephrology and Rheumatology, Niigata University, Niigata, Japan.
Kenichiro TanabeDivision of Health Data Science, Translational Research Center for Medical Innovation, Kobe, Japan.
Satoshi MoritaBiomedical Statistics and Bioinformatics, Kyoto University, Kyoto, Japan.
Yoshiharu TsubakiharaGraduate School of Health Care Sciences, Jikei Institute, Osaka, Japan.
Enyu ImaiNakayamadera Imai Clinic, Takarazuka, Japan.
Tadao AkizawaDivision of Nephrology, Showa University School of Medicine, Tokyo, Japan.
Shoichi MaruyamaDepartment of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Aichi, Japan. marus@med.nagoya-u.ac.jp.ORCID http://orcid.org/0000-0002-8858-632X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigher serum lactate dehydrogenase (LDH) levels are associated with poor prognosis including renal outcome, all-cause and cardiovascular mortality in patients with diabetic kidney disease. However, this association remains unclear in patients with chronic kidney disease (CKD) without diabetes mellitus (DM).

methodsUsing data from the PREDICT trial, which enrolled patients aged 20-85 years with an estimated glomerular filtration rate (eGFR) of 8-20 mL/min/1.73 m

resultsIn total, 444 patients (median age, 73 years; 61% men; mean eGFR, 13.5 mL/min/1.73 m

conclusionsHigher LDH levels are associated with higher risk of renal complications and composite of cardiovascular events or death in patients with advanced CKD without DM.

Indexed as

KidneyL-Lactate DehydrogenaseRenal Insufficiency, ChronicAdultAgedAged, 80 and overBiomarkersCardiovascular DiseasesFemaleGlomerular Filtration RateHumansMaleMiddle AgedPrognosisRisk FactorsTime FactorsBiomarkersL-Lactate DehydrogenaseAdvanced chronic kidney diseaseCardiovascular eventsLactate dehydrogenaseRenal outcome

Identifiers

PMID41984139
PMCPMC13242488

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.