Evidence map›Paper›PMID 41983955›Full record

ArticleJournal of immunology research2026

cTfh Cell Activation and Changes in BTLA and LAG-3 Expression Differentially Associate With Poor Pregnancy Outcome in Plasmodium falciparum Placental Malaria.

Bernard Marie Zambo Bitye, Chris Marco Mbianda Nana, Bodin Darcisse Kwanou Tchakounte, Balotin Fogang, Berenice Kenfack Tekougang Zangue, Reine Seumko'o Medouen Ndeumou, Lawrence Ayong, Rosette Megnekou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bernard Marie Zambo BityeDepartment of Animal Biology and Physiology, Faculty of Sciences, University of Yaoundé I, PO.BOX: 812, Yaoundé, Cameroon, uy1.uninet.cm.
Chris Marco Mbianda NanaDepartment of Animal Biology and Physiology, Faculty of Sciences, University of Yaoundé I, PO.BOX: 812, Yaoundé, Cameroon, uy1.uninet.cm.
Bodin Darcisse Kwanou TchakounteDepartment of Animal Biology and Physiology, Faculty of Sciences, University of Yaoundé I, PO.BOX: 812, Yaoundé, Cameroon, uy1.uninet.cm.
Balotin FogangMalaria Research Unit, Centre Pasteur du Cameroun, PO.BOX: 1274, Yaoundé, Cameroon, pasteur-yaounde.org.
Berenice Kenfack Tekougang ZangueDepartment of Animal Biology and Physiology, Faculty of Sciences, University of Yaoundé I, PO.BOX: 812, Yaoundé, Cameroon, uy1.uninet.cm.
Reine Seumko'o Medouen NdeumouDepartment of Animal Biology and Physiology, Faculty of Sciences, University of Yaoundé I, PO.BOX: 812, Yaoundé, Cameroon, uy1.uninet.cm.
Lawrence AyongMalaria Research Unit, Centre Pasteur du Cameroun, PO.BOX: 1274, Yaoundé, Cameroon, pasteur-yaounde.org.
Rosette MegnekouDepartment of Animal Biology and Physiology, Faculty of Sciences, University of Yaoundé I, PO.BOX: 812, Yaoundé, Cameroon, uy1.uninet.cm.ORCID https://orcid.org/0000-0003-0692-5197

Funding

TWAS and SIDA research grant 20-313 RG/BIO/AF/AC_G FR3240314171
6 · The paper itself

Abstract

Continuous exposure to antigens drives the activation of circulating T follicular helper (cTfh) cells, promoting high-affinity antibody production. However, sustained stimulation may impair their function through the upregulation of immunoregulatory markers like B and T lymphocyte attenuator (BTLA) and Lymphocyte-activation gene 3 (LAG-3). This study investigated the role of cTfh cells and their subsets in Plasmodium falciparum-associated placental malaria (PM). In a cross-sectional study conducted in Yaounde, Cameroon (March 2022-May 2023), peripheral, placental, and cord blood samples were collected from 49 women at delivery. Hemoglobin (Hb) levels were recorded, and peripheral blood mononuclear cells (PBMCs), intervillous blood mononuclear cell (IVBMCs), and cord blood mononuclear cells (CBMCs) were isolated for multiparametric flow cytometry analysis of cTfh cells and subsets (ICOS

Indexed as

Antigens, CDMalaria, FalciparumPlasmodium falciparumPregnancy Complications, ParasiticReceptors, ImmunologicT Follicular Helper CellsAdultCross-Sectional StudiesFemaleHumansLymphocyte ActivationLymphocyte Activation Gene 3 ProteinPlacentaPregnancyPregnancy OutcomeYoung AdultAntigens, CDBTLA protein, humanLymphocyte Activation Gene 3 ProteinReceptors, ImmunologiccTfh cellsimmunoregulatory markersplacental malariapregnancy outcomes

Identifiers

PMID41983955
PMCPMC13581053

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.