ArticleRevista da Sociedade Brasileira de Medicina Tropical2026
Sickle cell disease implicated in the development of severe dengue: A pediatric case series.
Article in Revista da Sociedade Brasileira de Medicina Tropical, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Dengue poses a considerable risk to individuals with sickle cell disease. This report presents six cases of male pediatric patients (mean age 9.7 ± 4.8 years) with a hemoglobin S mutation, all of whom exhibited clinical manifestations consistent with dengue infection. Diagnosis was confirmed using NS1 antigen, serology (IgM/IgG), and RT-PCR, identifying all cases as dengue virus serotype 2. All patients had warning signs at presentation; three were severe, four required intensive care, and one died from dengue shock. Early identification and management are critical to reduce mortality in children with hemoglobin S mutations during dengue epidemics.
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